COLONIC SECRETION OF WATER AND ELECTROLYTES INDUCED BY BILE ACIDS - PERFUSION STUDIES IN MAN
COLONIC SECRETION OF WATER AND ELECTROLYTES INDUCED BY BILE ACIDS - PERFUSION STUDIES IN MAN
复制标题
DOI：
10.1172/jci106644
复制
发表时间：
1971-01-01
影响因子：
15.9
通讯作者：
HOFMANN, AF
中科院分区：
文献类型：
--
作者：
MEKHJIAN, HS;PHILLIPS, SF;HOFMANN, AF
测试了人的三种主要胆汁酸中的每一种对人结肠中电解质和水吸收的影响。在35项研究中，对20名健康志愿者在稳态条件下通过结肠灌注从添加或不添加胆汁酸的等渗溶液中转运进行了比较。电解质和水总是从对照溶液中吸收，但二羟基胆汁酸溶液诱导持续分泌或抑制钠，钾和水的吸收，这是可逆的。脱氧胆酸在3 mm浓度引起一致的分泌，而鹅去氧胆酸不诱导分泌，直到浓度为5 mm。三羟基胆汁酸（胆酸）在10 mm的吸收没有产生显着变化。抑制吸收也诱导甘氨酸或牛磺酸结合胆汁酸的混合物。胆汁酸灌注诱导的钠和氯的分泌与水的分泌呈线性相关;钾的分泌相对恒定，与分泌量无关。这些结果建立了一个显着的影响，胆汁酸对结肠的吸收活性，提供了一个解释的腹泻，经常伴随回肠疾病或切除术的一部分，并暗示腹泻应该发生在其他疾病状态，产生浓度升高的二羟基胆汁酸在结肠腔。
Each of the three major bile acids of man was tested for its influence on electrolyte and water absorption in the human colon. Transport from isotonic solutions, with or without added bile acids, was compared in 35 studies on 20 healthy volunteers by colonic perfusions under steady-state conditions. Electrolytes and water were always absorbed from control solutions, but dihydroxy bile acid solutions induced continuous secretion or inhibition of sodium, potassium, and water absorption, which was reversible. Deoxycholic acid caused consistent secretion at 3 mmconcentrations, whereas chenodeoxycholic acid did not induce secretion until the concentration was 5 mm. The trihydroxy bile acid (cholic acid) produced no significant change in absorption at 10 mm. Inhibition of absorption was also induced by mixtures of the glycine or taurine conjugated bile acids. Secretion of sodium and chloride, induced by bile acid perfusion, was linearly correlated with secretion of water; potassium secretion was relatively constant regardless of the volume of secretion. These results establish a striking influence of bile acids on colonic absorptive activity, provide an explanation in part for the diarrhea that frequently accompanies ileal disease or resection, and imply that diarrhea should occur in other disease states that produce elevated concentrations of dihydroxy bile acids in the colonic lumen.