Reduced susceptibility to penicillin of viridans group streptococci in the oral cavity of patients with haematological disease.
Reduced susceptibility to penicillin of viridans group streptococci in the oral cavity of patients with haematological disease.
复制标题
血液病患者口腔中草绿色群链球菌对青霉素的敏感性降低。
DOI：
10.1111/j.1469-0691.2004.00975.x
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
C. Nord
中科院分区：
文献类型：
--
作者：
Katarina Westling;Inger Julander;P. Ljungman;Anders Heimdahl;A. Thalme;C. Nord
本文研究了50例新诊断急性白血病或自体外周血干细胞移植患者口服耐青霉素绿菌群链球菌（VGS）的发生情况。一名患者因在干细胞收获中发现金黄色葡萄球菌生长而被排除。从其余49例患者中48例的口腔中分离VGS。在这48例患者中，12例（25%）对青霉素产生了VGS耐药（MIC为2mg /L）。这12例患者的败血症发生率（p 0.04）高于易感或中耐药VGS （MIC 2 mg/L）患者（p 0.04），使用甲氧苄啶-磺胺甲恶唑治疗的天数（p 0.04）。两组之间没有其他统计学上的显著差异。重要的是要意识到血液系统疾病患者口服VGS对青霉素的高耐药性，在免疫功能低下患者中由VGS引起的败血症病例选择抗生素治疗时应考虑到这一参数。
The occurrence of oral penicillin-resistant viridans group streptococci (VGS) was studied in 50 patients with either newly diagnosed acute leukaemia or autologous peripheral stem cell transplants. One patient was excluded because of Staphylococcus aureus growth in the stem cell harvest. VGS were isolated from the oral cavity of 48 of the remaining 49 patients. Of these 48 patients, 12 (25%) yielded VGS resistant (MIC > 2 mg/L) to penicillin. These 12 patients had a higher frequency of septicaemia (p 0.04) and more days of treatment with trimethoprim-sulphamethoxazole (p 0.04) than patients who harboured susceptible or intermediately resistant VGS (MIC 2 mg/L). There were no other statistically significant differences between the two groups. It is important to be aware of the high level of penicillin resistance in oral VGS in patients with haematological disease, and this parameter should be considered when selecting antibiotic therapy for cases of septicaemia caused by VGS in immunocompromised patients.