Modeling to link regional myocardial work, metabolism and blood flows.
Modeling to link regional myocardial work, metabolism and blood flows.
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DOI：
10.1007/s10439-012-0613-5
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发表时间：
2012-11
影响因子：
3.8
通讯作者：
Vinnakota, Kalyan
中科院分区：
文献类型：
--
作者：
Bassingthwaighte, James B.;Beard, Daniel A.;Carlson, Brian E.;Dash, Ranjan K.;Vinnakota, Kalyan
关键词：
鉴于心脏兴奋和收缩的单功能，高度协调的过程，局部心肌血流量，rMBF，广泛异质性的观察引起了人们的关注，但尚未出现明确的解释。在离体和体内心脏研究中，发现总冠状动脉流量与心率-血压乘积（收缩期平均血压乘以心率）成比例，这是一种外部心脏工作的测量方法。同样的关系也可以在本地基础上实现：更多的工作需要更多的流量。这种预期的有效性从未在实验中得到证实。在这篇文章中，我们审查的概念联系细胞的兴奋和收缩工作，细胞能量和ATP需求，底物利用率，需氧量，血管调节和局部血流。这些过程的数学模型现在已经相当完善。我们建议，建设一个综合的模型，包括生物物理学，生物化学和生理学的心肌细胞收缩，然后结合一个详细的三维结构的纤维束和片安排的心脏作为一个整体，将框架的假设，可以定量评估，以解决主要问题：当地的工作驱动本地流在一个可预测的方式，解释了异质性？虽然在某种意义上，我们可以满足于功驱动心流是无可辩驳的，但没有心脏收缩模型证明局部应变-应力-功的异质性;恰恰相反，心脏收缩模型倾向于试图表明功应该是均匀的。本文的目的是论证工作的一致性不会发生，而且在任何情况下都是不可能的，并且有必要进行进一步的实验和分析来验证这一假设。
Given the mono-functional, highly coordinated processes of cardiac excitation and contraction, the observations that regional myocardial blood flows, rMBF, are broadly heterogeneous has provoked much attention, but a clear explanation has not emerged. In isolated and in vivo heart studies the total coronary flow is found to be proportional to the rate-pressure product (systolic mean blood pressure times heart rate), a measure of external cardiac work. The same relationship might be expected on a local basis: more work requires more flow. The validity of this expectation has never been demonstrated experimentally. In this article we review the concepts linking cellular excitation and contractile work to cellular energetics and ATP demand, substrate utilization, oxygen demand, vasoregulation, and local blood flow. Mathematical models of these processes are now rather well developed. We propose that the construction of an integrated model encompassing the biophysics, biochemistry and physiology of cardiomyocyte contraction, then combined with a detailed three-dimensional structuring of the fiber bundle and sheet arrangements of the heart as a whole will frame an hypothesis that can be quantitatively evaluated to settle the prime issue: Does local work drive local flow in a predictable fashion that explains the heterogeneity? While in one sense one can feel content that work drives flow is irrefutable, there are no cardiac contractile models that demonstrate the required heterogeneity in local strain-stress-work; quite the contrary, cardiac contraction models have tended toward trying to show that work should be uniform. The object of this review is to argue that uniformity of work does not occur, and is impossible in any case, and that further experimentation and analysis are necessary to test the hypothesis.
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DOI：
10.1152/ajpheart.00380.2003
发表时间：
2003-11-01
影响因子：
4.8
作者：
Beard, DA;Schenkman, KA;Feigl, EO
通讯作者：
Feigl, EO
DOI：
10.1152/ajpheart.00925.2009
发表时间：
2010-03-01
影响因子：
4.8
作者：
Algranati, Dotan;Kassab, Ghassan S.;Lanir, Yoram
通讯作者：
Lanir, Yoram
影响因子：
20.6
作者：
BASSINGTHWAIGHTE, JB;VANBEEK, JHGM
通讯作者：
VANBEEK, JHGM
DOI：
10.1016/0010-4809(68)90010-4
发表时间：
1968-01-01
期刊：
COMPUTERS AND BIOMEDICAL RESEARCH
影响因子：
--
作者：
ACHS, MJ;GARFINKEL, D
通讯作者：
GARFINKEL, D
DOI：
10.1196/annals.1302.034
发表时间：
2004-01-01
期刊：
CARDIAC ENGINEERING: FROM GENES AND CELLS TO STRUCTURE AND FUNCTION
影响因子：
--
作者：
Bassingthwaighte, JB;Vinnakota, KC
通讯作者：
Vinnakota, KC