VALEPOTRIATES, A NEW CLASS OF CYTO-TOXIC AND ANTI-TUMOR AGENTS
VALEPOTRIATES, A NEW CLASS OF CYTO-TOXIC AND ANTI-TUMOR AGENTS
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DOI：
10.1055/s-2007-971668
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发表时间：
1981-01-01
期刊：
影响因子：
2.7
通讯作者：
ANTON, R
中科院分区：
文献类型：
--
作者：
BOUNTHANH, C;BERGMANN, C;ANTON, R
Valtrate、baldrinal和didrovaltrate是从缬草Valeriana wallichii D. C.的方法，在体外对培养的大鼠肝癌细胞（HTC系）和在体内对雌性小鼠KREBS II腹水肿瘤进行活性测试。3种戊酸三酯对HTC肝癌细胞具有非常强的细胞毒性。地屈戊酸盐诱导KREBS II腹水肿瘤的可察觉的高百分比确定性缓解。
Valtrate, baldrinal and didrovaltrate, isolated from the roots of Valeriana wallichii D. C., were tested for activity in vitro on cultured rat hepatoma cells (HTC line) and in vivo on female mice KREBS II ascitic tumors. The 3 valepotriates are very potent cytotoxic agents for the HTC hepatoma cells. The didrovaltrate induces a perceptible high percent difinitive remission of the KREBS II ascitic tumors.