Serum Metabolomics Analysis in Wasp Sting Patients
Serum Metabolomics Analysis in Wasp Sting Patients
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DOI：
10.1155/2018/5631372
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发表时间：
2018-01-01
影响因子：
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通讯作者：
Fang, Zhicheng
中科院分区：
文献类型：
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作者：
Yang, Xianyi;Chai, Lin;Fang, Zhicheng
为了分析黄蜂蜇伤患者血清代谢组学的动态变化，我们在采集样本前3小时、24小时和72小时分别采集了10名健康志愿者和10名患者的血清。采用高效液相色谱-串联质谱（HPLC-MS/MS）技术进行代谢组学分析，并进行富集分析。共鉴定出838种代谢物。使用MetaboAnalyst进行的血清代谢组学分析显示，与健康对照组相比，3小时组患者有289种代谢物存在显著差异(P
To analyze the dynamic changes of serum metabolomics in wasp sting victims, we collected serum from 10 healthy volunteers and 10 patients who had been stung 3 hours, 24 hours, and 72 hours before sample collection. We analyzed the metabolomics by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) techniques and then performed enrichment analysis. A total of 838 metabolites were identified. Serum metabolomics analysis using MetaboAnalyst revealed 289 metabolites that were significantly different among patients in the 3-hour group versus healthy controls (P