RATES AND TISSUE SITES OF NON-INSULIN-MEDIATED AND INSULIN-MEDIATED GLUCOSE-UPTAKE IN HUMANS
RATES AND TISSUE SITES OF NON-INSULIN-MEDIATED AND INSULIN-MEDIATED GLUCOSE-UPTAKE IN HUMANS
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DOI：
10.1152/ajpendo.1988.255.6.e769
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发表时间：
1988-12-01
影响因子：
--
通讯作者：
EDELMAN, SV
中科院分区：
文献类型：
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作者：
BARON, AD;BRECHTEL, G;EDELMAN, SV
体内葡萄糖摄取可以通过两种机制发生，即胰岛素介导的葡萄糖摄取（IMGU）和非胰岛素介导的葡萄糖摄取（NIMGU）。虽然IMGU的主要组织部位是骨骼肌，但在给定血清葡萄糖浓度下NIMGU的组织部位尚不清楚。为了检查这个问题，在基础水平和在血糖正常的情况下进行葡萄糖钳夹研究期间测量了全身葡萄糖摄入率（Rd）（. apprx. 90 mg/dl）和高血糖症（约220 mg/dl）。研究在高胰岛素血症（. apprx. 70 μ U/ml）和在生长抑素诱导的胰岛素减少期间分别测量IMGU和NIMGU。在每项研究中，还测量了腿部葡萄糖平衡（动静脉导管技术）。通过这种方法，可以估计全身骨骼肌IMGU和NIMGU的比率，并且总体Rd和骨骼肌葡萄糖摄取之间的差异代表非骨骼肌Rd。结果表明，20%的基底Rd进入骨骼肌。在胰岛素减少期间86%的身体NIMGU发生在非骨骼肌组织中。当产生高血糖症时，全身NIMGU从128 . ±. 6到213 .+-. 18 mg/min（P < 0.01）; NIMGU进入非骨骼肌组织为134 . ±. 111 +-。6mg/min，P = NS。因此，几乎所有高血糖诱导的NIMGU增加都发生在骨骼肌中。在高胰岛素血症期间，在正常和高血糖时，骨骼肌中的IMGU分别占身体Rd的75%和95%。总之，绝大多数基础Rd是非胰岛素介导的，发生在非骨骼肌组织，主要是中枢神经系统（CNS）。由于Rd在生理葡萄糖水平下饱和，因此高血糖增加骨骼肌中的NIMGU，但不增加CNS中的NIMGU。
In vivo glucose uptake can occur via two mechanisms, namely, insulin-mediated glucose uptake (IMGU) and non-insulin-mediated glucose uptake (NIMGU). Although the principal tissue sites for IMGU are skeletal muscle, the tissue sites for NIMGU at a given serum glucose concentration are not known. To examine this issue, rates of whole body glucose uptake (Rd) were measured at basal and during glucose clamp studies performed at euglycemia (.apprx. 90 mg/dl) and hyperglycemia (.apprx. 220 mg/dl) in six lean healthy men. Studies were performed during hyperinsulinemia (.apprx. 70 .mu.U/ml) and during somatostatin-induced insulinopenia to measure IMGU and NIMGU, respectively. During each study, leg glucose balance (arteriovenous catheter technique) was also measured. With this approach, rates of whole body skeletal muscle IMGU and NIMGU can be estimated, and the difference between overall Rd and skeletal muscle glucose uptake represents non-skeletal muscle Rd. The results indicate that .apprx. 20% of basal Rd is into skeletal muscle. During insulinopenia .apprx. 86% of body NIMGU occurs in non-skeletal muscle tissues at euglycemia. When hyperglycemia was created, whole body NIMGU increased from 128 .+-. 6 to 213 .+-. 18 mg/min (P < 0.01); NIMGU into non-skeletal muscle tissues was 134 .+-. 11 and 111 .+-. 6 mg/min at hyperglycemia and euglycemia, respectively, P = NS. Therefore, virtually all the hyperglycemia induced increment in NIMGU occurred in skeletal muscle. During hyperinsulinemia, IMGU in skeletal muscle represented 75 and 95% of body Rd, at euglycemia and hyperglycemia, respectively. In conclusion, the great majority of basal Rd is non-insulin mediated and occurs in non-skeletal muscle tissues, chiefly the central nervous system (CNS). Since Rd saturates at physiological glucose levels, hyperglycemia increases NIMGU in skeletal muscle but not in the CNS.