Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma
Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma
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DOI：
10.1097/mpa.0b013e318279bd66
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发表时间：
2013-05-01
期刊：
影响因子：
2.9
通讯作者：
Tanaka, Masao
中科院分区：
文献类型：
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作者：
Mahawithitwong, Prawej;Ohuchida, Kenoki;Tanaka, Masao
目的：Kindlin-2是一种新发现的粘着斑蛋白，在乳腺癌、肺癌和胃癌中均有表达。本研究旨在探讨kindlin-2在胰腺导管腺癌中的表达及其意义。方法：对95例胰腺导管腺癌标本进行kindlin-2免疫组织化学检测。研究Kindlin-2的表达与胰腺癌临床病理参数及胰腺癌患者生存时间的关系。结果：Kindlin-2在PDAC瘤周间质中高表达。间质Kindlin-2的表达与淋巴结转移有关(P=0.03)。单因素分析显示，kindlin-2表达阳性患者的生存时间明显短于kindlin-2表达阴性患者(P=0.01)。此外，多因素分析显示Kindlin-2表达是PDAC患者R0切除术后预后不良的独立因素(RR=2.15；P=0.04)。结论：间质成分中Kindlin-2的表达与PDAC患者预后不良密切相关，提示Kindlin-2可作为预测PDAC患者预后的指标。
Objectives: Kindlin-2 is a novel focal adhesion protein reported to be expressed in breast, lung, and gastric cancers. This study aimed to investigate the significance of kindlin-2 expression in pancreatic ductal adenocarcinomas (PDACs).Methods: We performed immunohistochemical analysis on kindlin-2 on PDAC samples from 95 patients. We investigated the association between kindlin-2 expression and clinicopathological parameters of PDAC and the survival time of patients with PDAC who underwent pancreatectomy.Results: Kindlin-2 was highly expressed in the peritumoral stroma of PDACs. Stromal kindlin-2 expression was related to nodal metastasis (P = 0.03). Univariate analysis showed that patients with positive kindlin-2 expression had significantly shorter survival times than those with negative kindlin-2 expression (P = 0.01). In addition, multivariate analysis revealed that kindlin-2 expression was an independent factor of poor prognosis in patients with PDAC after R0 resection (RR = 2.15; P = 0.04).Conclusions: Kindlin-2 expression in stromal components is significantly associated with poor prognosis of patients with PDAC, suggesting that kindlin-2 is a prognostic marker for patients with PDAC.