Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Penn Sjogren's International Collaborative Clinical Alliance Cohort
Prevalence of Novel Candidate Sjogren Syndrome Autoantibodies in the Penn Sjogren's International Collaborative Clinical Alliance Cohort
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DOI：
10.1097/ico.0000000000002147
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发表时间：
2019-12-01
期刊：
影响因子：
2.8
通讯作者：
Ying, Gui-shuang
中科院分区：
文献类型：
--
作者：
Bunya, Vatinee Y.;Massaro-Giordano, Mina;Ying, Gui-shuang
目的：评估与干燥综合征(SS)相关的新候选自身抗体的患病率及其在宾夕法尼亚大学Sjogren国际协作临床联盟(SICCA)研究中登记的干眼症参与者中识别SS的能力。方法：作为SICCA研究的一部分，所有参与者都接受了全面的眼部和系统评估以确定可能的SS。用酶联免疫吸附试验检测唾液蛋白1(SP-1)、腮腺分泌蛋白(PSP)和碳酸氢酶6的自身抗体。结果：干眼症合并SS组(81例)和非SS组(129例)SP-1 IgM自身抗体阳性率明显高于非SS组(P=0.03)。同样，SS患者的PSPIgA自身抗体的患病率高于非SS干眼症患者(21%比11%；P=0.048)。合并SS和不合并SS的干眼症患者血清中碳酸氢酶6自身抗体的发生率分别为15%和20%，差异无统计学意义(P=0.36)。结论：在宾夕法尼亚大学SICCA队列中，SS相关干眼症患者血清中SP-1 IgM和PSP IgA自身抗体的发生率高于无SS患者。需要进一步的纵向研究来确定这些发现的临床意义。
Purpose: To evaluate the prevalence of novel candidate autoantibodies associated with Sjogren syndrome (SS) and their ability to identify those with SS among participants with dry eye enrolled in the Sjogren's International Collaborative Clinical Alliance (SICCA) study at the University of Pennsylvania (Penn).Methods: All participants previously underwent a full ocular and systemic evaluation for possible SS as part of the SICCA study. An enzyme-linked immunosorbent assay was used to detect IgG, IgA, and IgM autoantibodies to salivary protein 1 (SP-1), parotid secretory protein (PSP), and carbonic anhydrase 6 from previously banked baseline serum samples from SICCA study participants enrolled at Penn. The prevalence rate of each autoantibody, calculated by considering the presence of any isotype as antibody positive, was compared between participants with dry eye with SS (n = 81) or without SS (n = 129) using the Fisher exact test.Results: The prevalence of SP-1 IgM autoantibodies was higher in those with SS compared with those without SS (14% vs. 5%; P = 0.03). Similarly, the prevalence of PSP IgA autoantibodies was higher in those with SS compared with non-SS dry eye participants (21% vs. 11%; P = 0.048). There was no statistically significant difference in the prevalence of carbonic anhydrase 6 autoantibodies between those with or without SS (15% vs. 20%; P = 0.36).Conclusions: In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS. Further longitudinal studies are needed to determine the clinical significance of these findings.