Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women
Plasma calcidiol, season, and serum parathyroid hormone concentrations in healthy elderly men and women
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DOI：
10.1093/ajcn/65.1.67
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发表时间：
1997-01-01
影响因子：
7.1
通讯作者：
Dallal, GE
中科院分区：
文献类型：
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作者：
DawsonHughes, B;Harris, SS;Dallal, GE
冬季维生素D的减少会导致绝经后妇女甲状旁腺激素(PTH)浓度升高，加速骨质流失。我们进行了这项研究，以比较男性和女性的骨化二醇(25-羟基维生素D)浓度，考察季节、旅行、维生素D摄入量和其他变量对这些浓度的影响，并比较老年男性和女性骨化二醇和甲状旁腺素浓度之间的关系。在这项横断面研究中，年龄65岁的182名男性和209名女性的平均钙二醇浓度总体上高于女性((X)or bar+/-SD：82.4+/-35.8vs68.9+/-32.1nmol/L，P<；0.001)。在冬季(2-5月)测量的亚组中，男性(59.4+/-21.8，n=52)和女性(57.7+/-23.4nmol/L，n=83)的血浆钙二醇浓度较低，且无显著差异。在多元回归模型中，骨化二醇浓度与冬季旅行(P=0.012)、维生素D摄入量(P=0.002)和户外活动时间(P=0.096)呈正相关，而与体重(P<；0.001)和年龄(P=0.039)呈负相关。血浆钙二醇与血清甲状旁腺素浓度呈负相关，当钙二醇浓度降至110nmol/L以下时，甲状旁腺素缓慢升高(95可信区间：60,168nmol/L)。超过90%的男性和女性在冬季的钙二醇浓度低于此值。冬季骨化二醇值偏低的高发人群可能会增加老年男性和女性骨质丢失的风险。
Wintertime declines in vitamin D lead to increased concentrations of parathyroid hormone (PTH) and accelerated bone loss in postmenopausal women. We conducted this study to compare calcidiol (25-hydroxyvitamin D) concentrations of men and women, to examine the influence of season, travel, vitamin D intake, and other variables on these concentrations, and to compare associations between calcidiol and PTH concentrations in elderly men and women. In this cross-sectional study of 182 men and 209 women aged > 65 y, mean calcidiol concentrations were higher in men than in women overall ((x) over bar +/- SD: 82.4 +/- 35.8 compared with 68.9 +/- 32.1 nmol/L, P < 0.001). In the subset measured in winter (February-May), plasma calcidiol concentrations were lower and not significantly different in men (59.4 +/- 21.8, n = 52) and women (57.7 +/- 23.4 nmol/L, n = 83). In a multiple- regression model, calcidiol concentrations were positively influenced by wintertime travel (P = 0.012), vitamin D intake (P = 0.002), and time spent outdoors (P = 0.096) and negatively influenced by weight (P < 0.001) and age (P = 0.039). Plasma calcidiol and serum PTH concentrations were inversely related, with PTH rising slowly as calcidiol concentrations declined below 110 nmol/L (95 CI: 60, 168 nmol/L). More than 90% of the men and women had calcidiol concentrations below this value in the wintertime. The high prevalence of lower wintertime calcidiol values may increase risk of bone loss in elderly men and women.