Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.
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扩增的 C lambda 和 c-abl 基因位于 K562 白血病细胞的同一标记染色体上。
DOI：
10.1073/pnas.80.23.7289
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发表时间：
1983
影响因子：
11.1
通讯作者：
Croce,CM
中科院分区：
文献类型：
--
作者：
Selden,JR;Emanuel,BS;Wang,E;Cannizzaro,L;Palumbo,A;Erikson,J;Nowell,PC;Rovera,G;Croce,CM
人白血病细胞系K562来源于费城染色体阳性慢性髓性白血病患者，含有扩增的c-abl癌基因和未重排的C λ基因。使用原位杂交技术，我们已经确定，扩增的c-abl和C λ DNA序列的K562细胞都位于同一异常的近端着丝粒标记染色体，这可能代表一个改变费城染色体。
The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C lambda genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C lambda DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.