Racial Disparities in Prostate Cancer Incidence Rates by Census Division in the United States, 1999-2008
Racial Disparities in Prostate Cancer Incidence Rates by Census Division in the United States, 1999-2008
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DOI：
10.1002/pros.22958
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发表时间：
2015-05-15
期刊：
影响因子：
2.8
通讯作者：
Anderson, William F.
中科院分区：
文献类型：
--
作者：
Cook, Michael B.;Rosenberg, Philip S.;Anderson, William F.
背景在美国，男性前列腺癌的发病率高于白人男性，但发病率或种族差异在地理上是否存在差异却知之甚少。了解这些差异可能有助于未来对前列腺癌病因的研究。为了解决这一问题，我们利用国家癌症登记计划(NPCR)与监测、流行病学和最终结果(SEER)相结合的独特资源。方法前列腺癌计数和按种族(黑人、白人)、年龄、历年和美国人口普查部门划分的人口分母，1999-2008年期间，从NPCR和SEER中提取。我们计算了按种族和人口普查划分的年龄标准化发病率(ASR)和估计的年度百分比变化(EAPC)。我们按人口普查分区和日历周期评估了黑人和白人的发病率比率(BWIRR)。结果他的分析包括1,713,471例前列腺癌病例和12.17亿人年。黑人ASR从山区的每10万人年176人到大西洋中部的259人不等。西区的BWIRR为1.20，东南区为1.72。EAPC表明，与所有其他地区不同，中南部东部地区的前列腺癌发病率并未下降。白人EAPC在人口普查分区中显示出类似的变化，导致BWIRR在时间上的适度变化。结论在美国，前列腺癌发病率存在显著的地理差异。尽管BWIRR存在很大的地理差异，但时间趋势相当稳定。这可能表明，影响前列腺癌发病率的主要因素因地域而异，但对黑人和白人男性的影响程度相似。前列腺癌75：758-763,2015。2015年出版。这篇文章是美国政府的工作，属于美国的公共领域。
BACKGROUNDBlack men have a higher incidence of prostate cancer than white men in the U.S., but little is known whether incidence or racial differences vary geographically. Understanding these differences may assist future studies on causes of prostate cancer. To address such, we leverage the unique resource of the National Program of Cancer Registries (NPCR) combined with Surveillance, Epidemiology and End Results (SEER).METHODSProstate cancer counts and population denominators by race (black, white), age, calendar year, and U.S. census division, for the period 1999-2008, were extracted from NPCR and SEER. We calculated age-standardized incidence rates (ASR) and estimated annual percent changes (EAPC) by race and census division. We assessed black-to-white incidence rate ratios (BWIRR) by census division and by calendar period.RESULTSThis analysis included 1,713,471 prostate cancer cases and 1,217 million person-years. Black ASRs ranged from 176 per 100,000 person-years in Mountain division to 259 in Middle Atlantic. BWIRRs ranged from 1.20 in Western divisions to 1.72 in Southeastern divisions. EAPCs indicated that prostate cancer incidence is not decreasing in East South Central, unlike all other divisions. White EAPCs displayed similar variations by census division, resulting in modest temporal changes in BWIRRs.CONCLUSIONSWithin the U.S., there exists significant geographic variability in prostate cancer incidence rates. Although there are large geographic differences in BWIRRs, temporal trends are fairly stable. This may indicate that primary factors affecting prostate cancer incidence rates vary geographically but affect both black and white men to a similar degree. Prostate 75: 758-763, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.