A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients.
A prospective comparison of neuropsychologic function in HIV-seropositive and seronegative methadone-maintained patients.
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HIV 血清阳性和血清阴性美沙酮维持患者神经心理功能的前瞻性比较。
DOI：
10.1097/00002030-199006000-00011
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发表时间：
1990
期刊：
影响因子：
3.8
通讯作者：
G. Friedland
中科院分区：
文献类型：
--
作者：
F. Mckegney;M. O’Dowd;C. Feiner;P. Selwyn;E. Drucker;G. Friedland
一项前瞻性纵向研究的神经心理和心理社会功能的美沙酮维持人口开始测试的假设，认知障碍可能存在于早期的HIV感染过程中，其他身体症状的发作之前。共有220名没有艾滋病毒相关疾病证据的美沙酮诊所患者接受了基线心理筛查测试以及艾滋病毒抗体血清学测试。在基线时，83例（38%）有HIV抗体，137例（62%）没有。在控制种族/民族、年龄、性别和药物使用的初始测试中，血清阳性者比血清阴性者认知受损更严重。单变量分析中，手指敲击（显性）、手指跨度（向前）和相似性三个分测验的差异有统计学意义。91例患者，其目前的血清学状态是已知的，从基线测试平均间隔7.4个月后，给予后续的神经心理和心理社会评估。在随访时，血清阳性者的认知功能受损程度继续高于血清阴性者，但在此时间间隔内，初始血清阳性者的表现没有恶化。
A prospective longitudinal study of neuropsychological and psychosocial functioning in a methadone-maintained population was initiated to test the hypothesis that cognitive impairments may be present early in the course of HIV infection, before the onset of other physical symptoms. A total of 220 methadone-clinic patients without evidence of HIV-related illnesses were given baseline psychological screening tests, as well as serological testing for HIV antibodies. At baseline, 83 (38%) had antibodies to HIV and 137 (62%) did not. On initial testing, controlling for race/ethnicity, age, sex and drug use, the seropositives were more cognitively impaired than the seronegatives. The differences were statistically significant for three subtests on univariate analysis: finger tapping (dominant), digit span (forward) and similarities. Ninety-one patients whose current serological status was known were given follow-up neuropsychological and psychosocial assessments after a mean interval of 7.4 months from baseline testing. At follow-up, seropositives continued to be more cognitively impaired than seronegatives, but there was no deterioration in the performance of the initial seropositives over the time interval.