Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence
Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence
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DOI：
10.3748/wjg.v13.i16.2283
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发表时间：
2007-04-28
影响因子：
4.3
通讯作者：
Tsujimura, Tohru
中科院分区：
文献类型：
--
作者：
Yoshikawa, Reigetsu;Fujiwara, Yoshinori;Tsujimura, Tohru
目的：探讨环氧合酶-2（COX-2）与血管内皮生长因子（VEGF）的关系，并探讨这种关系在食管癌放化疗（CRT）患者中的临床意义。方法：采用免疫组织化学染色法检测40例术前经组织学证实的食管鳞癌（ESCC）患者中COX-2和VEGF的表达情况。 CRT 结果：40 名 ESCC 患者中有 14 名在 CRT 后显示出病理学完全缓解 (CR)。 17个和13个肿瘤的细胞质中分别观察到COX-2和VEGF蛋白表达，分别在9个和13个肿瘤中没有表达。 COX-2表达与VEGF表达呈强相关(P < 0.05)。 COX-2 表达、肿瘤复发和淋巴结受累之间也存在显着相关性（分别为 P = 0.0277 和 P = 0.0095）。通过单变量分析评估，COX-2 表达和 VEGF 表达对于无病生存具有显着的预后价值（对数秩检验；分别为 P = 0.0073 和 P = 0.0341），但对于总生存没有显着的预后价值。 结论：我们的结果表明，COX-2 表达与 VEGF 表达相关，并且可能是接受新辅助 CRT 的 ESCC 患者更频繁肿瘤复发的有用预后因素。这些发现支持使用抗血管生成 COX-2 抑制剂治疗 ESCC。 (C) 2007 年 WJG 出版社。版权所有。
AIM: To investigate the relationship between cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF), and to determine the clinical significance of this relationship in esophageal cancer patients undergoing chemoradiotherapy (CRT).METHODS: Immunohistochemical staining was used to evaluate COX-2 and VEGF expression in 40 patients with histologically-confirmed esophageal squamous carcinoma (ESCC) who were undergoing preoperative CRT.RESULTS: Fourteen out of 40 ESCC patients showed a pathological complete response (CR) after CRT. COX-2 and VEGF protein expressions were observed in the cytoplasm of 17 and 13 tumors, respectively, with null expression in 9 and 13 tumors, respectively. COX-2 expression was strongly correlated with VEGF expression (P < 0.05). There were also significant associations between COX-2 expression, tumor recurrence, and lymph-node involvement (P = 0.0277 and P = 0.0095, respectively). COX-2 expression and VEGF expression had significant prognostic value for disease-free survival (log-rank test; P = 0.0073 and P = 0.0341, respectively), but not for overall survival, as assessed by univariate analysis.CONCLUSION: Our results suggest that COX-2 expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in ESCC patients undergoing neoadjuvant CRT. These findings support the use of anti-angiogenic COX-2 inhibitors in the treatment of ESCC. (C) 2007 The WJG Press. All rights reserved.