Reduced lower extremity vibratory perception in osteoarthritis of the knee
Reduced lower extremity vibratory perception in osteoarthritis of the knee
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DOI：
10.1002/art.23241
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发表时间：
2008-01-15
期刊：
影响因子：
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通讯作者：
Block, Joel A.
中科院分区：
文献类型：
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作者：
Shakoor, Najia;Agrawal, Alan;Block, Joel A.
目标。振动感知阈值（VPT）评估与神经性关节病相关的不同但相关的感觉通路，但尚未在膝骨关节炎（OA）中进行评估。本研究的目的是评估膝关节OA患者的VPT，以确定膝关节OA中观察到的下肢传入功能障碍是否不仅仅涉及本体感觉。27名有症状和影像学表现的膝关节OA患者与14名年龄匹配的正常受试者进行了比较。使用生物等距仪评估VPT。评估下肢的五个部位。将OA组与正常人的VPT进行比较。与正常受试者相比，OA组的VPT在5个测试点均显著降低（P < 0.05）。骨性关节炎患者和正常人的VPT评分（平均+/- SEM伏特）如下：第一跖趾关节（15.0 +/- 1.9比6.4 +/- 0.9），内踝（22.0 +/- 2.2比12.3 +/- 1.4），外踝（22.3 +/- 2.0比10.4 +/- 0.8），股骨内侧髁（25.8 +/- 1.8比15.9 +/- 1.9），股骨外侧髁（27 +/- 1.9比18.9 +/- 2.4）。这是第一项评估OA患者VPT的研究，并证明膝关节OA患者下肢VPT减少。注意到的VPT缺陷可能在OA的神经力学病理生理学中具有重要意义。VPT是一种简单可靠的测量膝关节OA患者感觉缺陷的技术。
Objective. Vibratory perception threshold (VPT) assesses a distinct yet related sensory pathway that has been associated with neuropathic arthropathy but has not been assessed in knee osteoarthritis (OA). The purpose of this study was to evaluate VPT in subjects with knee OA to determine whether the lower extremity afferent deficits observed in knee OA involve more than just proprioception.Methods. Twenty-seven individuals with symptomatic and radiographic knee OA were compared with 14 age-matched normal subjects. VPT was assessed using a biothesiometer. Five sites of the lower extremity were evaluated. VPT of OA subjects was compared with VPT of normal subjects.Results. VPT of the OA subjects was significantly reduced at all 5 testing sites compared with normal subjects (P < 0.05 at all sites). VPT scores (mean +/- SEM volts) for OA subjects and normal subjects were as follows: first metatarsophalangeal joint (15.0 +/- 1.9 versus 6.4 +/- 0.9), medial malleolus (22.0 +/- 2.2 versus 12.3 +/- 1.4), lateral malleolus (22.3 +/- 2.0 versus 10.4 +/- 0.8), medial femoral condyle (25.8 +/- 1.8 versus 15.9 +/- 1.9), and lateral femoral condyle (27 +/- 1.9 versus 18.9 +/- 2.4).Conclusion. This was the first study to evaluate VPT in OA and demonstrate that VPT is reduced at the lower extremity of subjects with knee OA. The noted deficits in VPT may have significant implications in the neuromechanical pathophysiology of OA. VPT is a simple and reliable technique to measure sensory deficits in subjects with OA of the knee.