Association and dissociation between laser-evoked potentials and pain perception
Association and dissociation between laser-evoked potentials and pain perception
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DOI：
10.1097/00001756-199712010-00026
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发表时间：
1997-12-01
期刊：
影响因子：
1.7
通讯作者：
Mauguiere, F
中科院分区：
文献类型：
--
作者：
GarciaLarrea, L;Peyron, R;Mauguiere, F
我们研究了主观疼痛感觉与激光诱发电位的两个不同成分之间的关系，即顶点反应（N220-P350）和早期偏侧反应（中潜伏期NP 160）。在15名受试者中，在注意和分心的条件下获得了对激光刺激的脑反应。虽然刺激强度保持恒定，但当受试者参加刺激时，它被认为是显着更高的。主观强度知觉与顶电位波幅呈正相关，与中潜伏期成分无相关性。虽然激光顶点电位可以反映决定主观体验的注意力/感知机制，但NP 160表现为感知前感觉反应，这在早期皮质疼痛处理的评估中应该是有利的。
WE investigated the relation between the subjective sensation of pain and two different components of the laser evoked potential, namely the vertex response (N220-P350) and an earlier lateralized response (middle-latency NP160). Brain responses to laser stimuli were obtained in 15 subjects under attentive and distractive conditions. Although stimulus intensity was kept constant, it was perceived as significantly higher when subjects attended the stimulation. There was a positive correlation between subjective intensity perception and the amplitude of the vertex potential, but no correlation existed with the middle-latency component. While laser vertex potentials may reflect attentional/perceptual mechanisms that determine subjective experience, the NP160 behaves as a pre-perceptual sensory response that should be advantageous in the assessment of early cortical pain processing.