Macroprolactinemia in Childhood and Adolescence: A Cause of Asymptomatic Hyperprolactinemia
Macroprolactinemia in Childhood and Adolescence: A Cause of Asymptomatic Hyperprolactinemia
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儿童和青少年时期的巨催乳素血症：无症状高催乳素血症的原因
DOI：
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发表时间：
2000
影响因子：
3.2
通讯作者：
P. Sobrado
中科院分区：
文献类型：
--
作者：
H. Fideleff;G. Ruibal;H. Boquete;Andrea B. Pujol;A. Sequera;P. Sobrado
无症状高催乳素血症与循环催乳素（PRL）分子形式比例改变相关，已在成人中报告。在儿童和青少年中缺乏参考文献促使我们报告我们在评估和随访巨泌乳素血症患者方面的经验。我们研究了5例患者（1男4女），年龄11.6-18岁，偶然发现无症状高泌乳素血症。患者接受了3个月至8年的重复评估，其PRL水平仍然升高（34.4-516 ng/ml）。PRL ≥45 kD的结构变异范围为58.9 - 78.6%。色谱图显示5例病例中的Big Big PRL增加，范围在40 - 72%之间（正常：9-21%），3例病例中的Big PRL增加，范围在30.0 - 32.6%之间（正常：5-25%）。所有病例的PRL均略有下降，范围为20.6%至41.1%（正常：50%至90%）。总之，当检测到高催乳素血症，没有临床表现，也没有改变其余的内分泌功能，巨催乳素血症应被认为是一个可能的诊断。在随访期间确认没有功能改变将有利于无治疗方法，同时避免重复成像研究。
Asymptomatic hyperprolactinemias associated with altered proportions of molecular forms of circulating prolactin (PRL) have been reported in adults. The scarce references available in children and adolescents prompted us to report our experience in the evaluation and follow-up of patients with macroprolactinemia. We studied 5 patients (1 male and 4 females) aged 11.6–18 years with incidentally discovered asymptomatic hyperprolactinemia. Patients underwent repeated evaluations for a period of 3 months to 8 years, and their PRL levels remained elevated (34.4–516 ng/ml). Structural variants of PRL ≥45 kD ranged between 58.9 and 78.6%. Chromatographic profiles showed increases in Big Big PRL in the 5 cases, ranging between 40 and 72% (normal: 9–21%), and in Big PRL in 3 cases, ranging between 30.0 and 32.6% (normal: 5–25%). Little PRL was decreased in all cases, ranging between 20.6 and 41.1% (normal: 50– 90%). In conclusion, upon detection of hyperprolactinemia with no clinical manifestations and no alteration of the remaining endocrine functions, macroprolactinemia should be considered as a possible diagnosis. The confirmed absence of functional alterations during the follow-up would favor a no-treatment approach and at the same time avoid repeating imaging studies.
由于存在巨催乳素血症而延迟诊断心理性勃起功能障碍。
DOI：
10.1210/jcem.81.7.8675569
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Guay,AT;Sabharwal,P;Varma,S;Malarkey,WB
通讯作者：
Malarkey,WB
两例巨泌乳素血症患者血清泌乳素性质的探讨。
影响因子：
6.7
作者：
Carlson,HE;Markoff,E;Lee,DW
通讯作者：
Lee,DW