Protective Effects of Urinary Trypsin Inhibitor on Vascular Permeability Following Subarachnoid Hemorrhage in a Rat Model
Protective Effects of Urinary Trypsin Inhibitor on Vascular Permeability Following Subarachnoid Hemorrhage in a Rat Model
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DOI：
10.1111/cns.12122
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发表时间：
2013-09
影响因子：
5.5
通讯作者：
Ningsun Zhou;Ting Xu;Ying Bai;Sherchan Prativa;Jiazheng Xu;Kai Li;Hong-bin Han;Jun-hao Yan
中科院分区：
文献类型：
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作者：
Ningsun Zhou;Ting Xu;Ying Bai;Sherchan Prativa;Jiazheng Xu;Kai Li;Hong-bin Han;Jun-hao Yan
蛛网膜下腔出血（SAH）后，炎症和细胞凋亡在增加血管通透性中起重要作用。本研究旨在探讨丝氨酸蛋白酶抑制剂尿胰蛋白酶抑制剂（UTI）在实验性SAH后是否通过抗炎和抗凋亡作用降低血管通透性。
Inflammation and apoptosis play important roles in increasing vascular permeability following subarachnoid hemorrhage (SAH). The objective of this study was to evaluate whether urinary trypsin inhibitor (UTI), a serine protease inhibitor, attenuates vascular permeability by its antiinflammatory and antiapoptotic effects after experimental SAH.