Anticancer, antioxidant and antimicrobial activities of the essential oil of Lycopus lucidus Turcz. var. hirtus Regel
Anticancer, antioxidant and antimicrobial activities of the essential oil of Lycopus lucidus Turcz. var. hirtus Regel
复制标题
番茄精油的抗癌、抗氧化和抗菌活性。
DOI：
10.1016/j.foodchem.2010.12.027
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发表时间：
2011-06-15
期刊：
影响因子：
8.8
通讯作者：
Zou, Guo-lin
中科院分区：
文献类型：
--
作者：
Yu, Jian-Qing;Lei, Jia-Chuan;Zou, Guo-lin
研究了泽兰挥发油的抗肿瘤、抗氧化和抑菌活性。变种希图斯·瑞格尔精油对六种人类癌细胞系的处理导致细胞生长的剂量依赖性抑制。挥发油对肝癌和乳腺癌细胞株的细胞毒作用明显强于其他细胞株。挥发油能诱导肝癌细胞Bel-7402凋亡，降低细胞内GSH水平。以2，2-二苯基-1-苦基肼（DPPH）和羟自由基（OH）为指标，评价了其抗氧化作用。清除测定。该精油具有中等的抗氧化活性。采用纸片扩散法和肉汤微量稀释法对8种微生物进行了抗菌活性评价。精油还显示出中等的抗菌活性。这些表明，精油可以在制药工业中使用具有良好的潜力。(C)2010爱思唯尔有限公司保留所有权利。
This study was designed to examine the anticancer, antioxidant and antimicrobial activities of the essential oil from Lycopus lucidus Turcz. var. hirtus Regel. The essential oil treatment to six human cancer cell lines resulted in a dose-dependent inhibition of cell growth. The cytotoxicity of the essential oil on liver carcinoma and breast cancer cell lines was significantly stronger than on other cell lines. The essential oil can induce apoptosis of the liver carcinoma cell line Bel-7402 and decrease the intracellular GSH level. The antioxidant effect of the essential oil was evaluated by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl radical (OH.) scavenging assays. The essential oil exhibited moderate antioxidant activity. The antimicrobial activity of the essential oil was evaluated against eight microorganisms using the disc diffusion and broth microdilution methods. The essential oil also showed moderate antimicrobial activity. These suggest that the essential oil could hold a good potential for use in the pharmaceutical industry. (C) 2010 Elsevier Ltd. All rights reserved.