Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia.
Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia.
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DOI：
10.1038/sj.jp.7211020
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发表时间：
2004-01-01
期刊：
影响因子：
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通讯作者：
Brown, Lou Ann S
中科院分区：
文献类型：
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作者：
Manar, Martha H;Brown, Milton R;Brown, Lou Ann S
目的：活性氧（ROS）参与氧化性肺损伤。谷胱甘肽- s -转移酶（GST）家族和微粒体环氧化物水解酶（mEPHx）酶解毒ROS，遗传多态性改变这种解毒。我们假设编码低效率酶的多态性与支气管肺发育不良（BPD）有关。研究设计：我们在35例BPD病例和98例对照的初步研究中确定了这些多态性的等位基因分布。进行Chi2和回归分析。结果：GST P1等位基因在各组间的分布存在差异，有效的val/val等位基因在对照组中占主导地位（p<或=0.05）。在控制种族和性别的情况下，BPD病例不太可能是val/val同种异构体的纯合子（OR 0.21, CI: 0.045-0.95, p=0.04），而更可能具有效率较低的ile同种异构体（OR 4.5, CI: 1.0-20.7, p=0.05）。结论：这项初步研究表明BPD与GST-P1 105ile等位基因的存在有关。未来的前瞻性研究是必要的。
OBJECTIVE: Reactive oxygen species (ROS) contribute to oxidative lung injury. The glutathione-S-transferases (GST) family and microsomal epoxide hydrolase (mEPHx) enzymes detoxify ROS, and genetic polymorphisms alter this detoxification. We hypothesized that polymorphisms encoding for less efficient enzymes were associated with bronchopulmonary dysphasia (BPD).STUDY DESIGN: We determined allelic distribution of these polymorphisms in a pilot study of 35 BPD cases and 98 controls. chi2 and regression analysis were performed.RESULTS: GST P1 val105ile distribution differed between the groups, with the more efficient val/val allele predominantly in controls (p< or =0.05). When controlling for race and sex, BPD cases were less likely to be homozygotes for the val/val isoform (OR 0.21, CI: 0.045-0.95, p=0.04) and more likely to possess the less efficient ile isoform (OR 4.5, CI: 1.0-20.7, p=0.05).CONCLUSIONS: This pilot study suggests that BPD is associated with the presence of the GST-P1 105ile allele. Future prospective studies are warranted.