Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment.
Nanoscintillator-mediated X-ray inducible photodynamic therapy for in vivo cancer treatment.
复制标题
纳米闪烁体介导的 X 射线诱导光动力疗法用于体内癌症治疗。
DOI：
10.1021/nl504044p
复制
发表时间：
2015-04-08
期刊：
影响因子：
10.8
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Chen H;Wang GD;Chuang YJ;Zhen Z;Chen X;Biddinger P;Hao Z;Liu F;Shen B;Pan Z;Xie J
光动力疗法是一种很有前途的治疗方法，但由于可见光的浅穿透性，其应用受到限制。在这里，我们报告了一种新的X射线诱导光动力疗法(X-PDT)方法，它允许PDT受到X射线的调节。在X射线照射下，由纳米闪烁体和负载光敏剂的介孔二氧化硅涂层组成的集成纳米系统将X射线光子转换为可见光光子，激活光敏剂，导致有效的肿瘤缩小。
Photodynamic therapy is a promising treatment method, but its applications are limited by the shallow penetration of visible light. Here, we report a novel X-ray inducible photodynamic therapy (X-PDT) approach that allows PDT to be regulated by X-rays. Upon X-ray irradiation, the integrated nanosystem, comprised of a core of a nanoscintillator and a mesoporous silica coating loaded with photosensitizers, converts X-ray photons to visible photons to activate the photosensitizers and cause efficient tumor shrinkage.