The maternal-to-zygotic transition: a play in two acts
The maternal-to-zygotic transition: a play in two acts
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DOI：
10.1242/dev.033183
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发表时间：
2009-09-15
期刊：
影响因子：
4.6
通讯作者：
Lipshitz, Howard D.
中科院分区：
文献类型：
--
作者：
Tadros, Wael;Lipshitz, Howard D.
所有动物胚胎都会经历一个阶段，在此阶段，发育控制从母体提供的基因产物转移到合子基因组合成的基因产物。这种母体向合子转变（MZT）已在模式生物中得到广泛研究，包括棘皮动物、线虫、昆虫、鱼类、两栖动物和哺乳动物。在所有情况下，MZT 都可以细分为两个相互关联的过程：首先，母体 mRNA 和蛋白质的子集被消除；其次，合子转录启动。这两个事件的时间和规模因物种而异，塑造胚胎的细胞和形态发生过程也不同。在本文中，我们讨论 MZT 的两个组成过程中保守且独特的特征。
All animal embryos pass through a stage during which developmental control is handed from maternally provided gene products to those synthesized from the zygotic genome. This maternal-to-zygotic transition (MZT) has been extensively studied in model organisms, including echinoderms, nematodes, insects, fish, amphibians and mammals. In all cases, the MZT can be subdivided into two interrelated processes: first, a subset of maternal mRNAs and proteins is eliminated; second, zygotic transcription is initiated. The timing and scale of these two events differ across species, as do the cellular and morphogenetic processes that sculpt their embryos. In this article, we discuss conserved and distinct features within the two component processes of the MZT.