Intersectin scaffold proteins and their role in cell signaling and endocytosis.
Intersectin scaffold proteins and their role in cell signaling and endocytosis.
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DOI：
10.1016/j.bbamcr.2016.10.005
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
O'Bryan JP
中科院分区：
文献类型：
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作者：
Herrero-Garcia E;O'Bryan JP
交叉蛋白是一个多结构域蛋白家族，参与多种细胞通路的调控。这些支架蛋白是众所周知的调节内吞作用，但也在细胞信号通路中发挥重要作用，包括激酶调节和Ras激活。itns参与多种人类癌症，如神经母细胞瘤和胶质母细胞瘤，而其下调与肺损伤有关。在神经退行性疾病如唐氏综合症和阿尔茨海默病中发现了ITSN表达的改变。itns的结合蛋白包括内吞调节因子、细胞骨架相关蛋白（即肌动蛋白或动力蛋白）、信号蛋白以及疱疹病毒蛋白。本文将对itns的最新研究进行综述，强调这些支架蛋白在上述过程中的重要性。
Intersectins (ITSNs) are a family of multi-domain proteins involved in regulation of diverse cellular pathways. These scaffold proteins are well known for regulating endocytosis but also play important roles in cell signaling pathways including kinase regulation and Ras activation. ITSNs participate in several human cancers, such as neuroblastomas and glioblastomas, while its downregulation is associated with lung injury. Alterations in ITSN expression have been found in neurodegenerative diseases such as Down Syndrome and Alzheimer’s disease. Binding proteins for ITSNs include endocytic regulatory factors, cytoskeleton related proteins (i.e. actin or dynamin), signaling proteins as well as herpes virus proteins. This review will summarize recent studies on ITSNs, highlighting the importance of these scaffold proteins in the aforementioned processes.