Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent
Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent
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DOI：
10.1007/s00330-004-2339-8
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发表时间：
2004-11-01
影响因子：
5.9
通讯作者：
Clement, O
中科院分区：
文献类型：
--
作者：
Fournier, LS;Cuenod, CA;Clement, O
采用大分子增强功能性CT研究肝细胞癌早期的血流灌注变化。14只化学诱导的大鼠原发性肝肿瘤，病理范围从增生到肝细胞癌，以及15只对照大鼠。在诱导肿瘤后11周和18周分别在同一切片上用实验性大分子造影剂进行两次动态CT扫描，然后进行病理检查。应用去卷积数学模型，得到肝血流灌注指数(HPI)、平均通过时间(MTT)、肝脏分布体积(LDV)以及动脉、门静脉和总血流量(FA、FP、FT)。每只大鼠一张切片进行分析，总共包括2例增生、6例异型增生和15例肝细胞癌。在第一次扫描中，早期病理阶段的肝癌的FP较低(-30%，P=0.002)，但动脉-门静脉平衡正常。在与病理同时进行的扫描中，肝细胞癌血流灌注参数显示肝动脉-门脉平衡倒置(HPI+212%，P
Macromolecular contrast-enhanced functional CT was performed to characterize early perfusion changes in hepatocellular carcinoma (HCC). Fourteen rats with chemically induced primary liver tumors ranging pathologically from hyperplasia to HCC and 15 control rats were investigated. Two dynamic CT scans using an experimental macromolecular contrast agent were performed on a single slice 11 and 18 weeks after tumor induction followed by pathological examination. A deconvolution mathematical model was applied, yielding the hepatic perfusion index (HPI), mean transit time (MTT), liver distribution volume (LDV) and arterial, portal and total blood flows (FA, FP, FT). Analysis was performed on one slice per rat, containing overall two hyperplasia, six dysplasia and 15 HCC. On the first scans, HCC at an early pathological stage had a low FP (-30%, P=0.002) but a normal arterial-portal balance. On the scan contemporary to pathology, HCC perfusion parameters showed an inversion of the arterial-portal balance (HPI +212%, P