Exercise and the Development of the Artificial Pancreas: One of the More Difficult Series of Hurdles.
Exercise and the Development of the Artificial Pancreas: One of the More Difficult Series of Hurdles.
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DOI：
10.1177/1932296815609370
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发表时间：
2015-10-01
影响因子：
5
通讯作者：
Jamnik, Veronica K
中科院分区：
文献类型：
--
作者：
Riddell, Michael C;Zaharieva, Dessi P;Jamnik, Veronica K
规律的身体活动（PA）对1型糖尿病患者（T1D）有许多健康益处。然而，PA也使血糖控制复杂化。影响PA期间血糖波动的因素包括活动类型、强度和持续时间，以及活动时体内胰岛素和食物的量。为了在PA期间维持血糖浓度的平衡，血液中葡萄糖出现（Ra）到消失（Rd）的速率必须平衡。在非糖尿病患者中，在轻度至中度有氧PA发作时，胰高血糖素升高，胰岛素释放减少。在高强度的有氧-无氧工作中，胰岛素释放先减少，然后在恢复早期迅速上升，以抵消反调节激素和代谢物的急剧增加。“运动智能”人工胰腺（AP）必须能够感知葡萄糖和其他对各种类型和强度的PA的生理反应。这项新技术的出现可能使易患低血糖和高血糖的活动型T1D患者受益。
Regular physical activity (PA) promotes numerous health benefits for people living with type 1 diabetes (T1D). However, PA also complicates blood glucose control. Factors affecting blood glucose fluctuations during PA include activity type, intensity and duration as well as the amount of insulin and food in the body at the time of the activity. To maintain equilibrium with blood glucose concentrations during PA, the rate of glucose appearance (Ra) to disappearance (Rd) in the bloodstream must be balanced. In nondiabetics, there is a rise in glucagon and a reduction in insulin release at the onset of mild to moderate aerobic PA. During intense aerobic -anaerobic work, insulin release first decreases and then rises rapidly in early recovery to offset a more dramatic increase in counterregulatory hormones and metabolites. An "exercise smart" artificial pancreas (AP) must be capable of sensing glucose and perhaps other physiological responses to various types and intensities of PA. The emergence of this new technology may benefit active persons with T1D who are prone to hypo and hyperglycemia.