Inhibitory effect of apelin-12 on nocturnal food intake in the rat
Inhibitory effect of apelin-12 on nocturnal food intake in the rat
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DOI：
10.1080/1028415031000111273
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发表时间：
2003-06-01
影响因子：
3.6
通讯作者：
Morris, MJ
中科院分区：
文献类型：
--
作者：
O'Shea, M;Hansen, MJ;Morris, MJ
APJ受体的内源性多肽配体apelin在大脑中与食物和水摄入有关的区域表达。这项研究首次报道了apelin-12，一种最有效的apelin多肽，对自发(夜间)进食的影响。随机脑室注射1、3和10nmolapelin-12或生理盐水，在熄灯前10分钟，导致注射后2-4小时摄食量呈剂量依赖性减少(n=7；p
Apelin, the endogenous peptide ligand of the APJ receptor, is expressed in brain regions implicated in food and water intake.. This study reports for the first time, the effect of apelin-12, one of the most potent apelin peptides, on spontaneous (nocturnal) feeding. Randomised intracerebroventricular injection of 1, 3 and 10 nmol apelin-12 or saline vehicle, 10 min prior to lights out, led to dose-dependent reductions in food intake 2-4 h after injection (n=7; p