STUDIES ON CAFE-AU-LAIT SPOTS IN NEUROFIBROMATOSIS AND PIGMENTED MACULES OF NEVUS-SPILUS
STUDIES ON CAFE-AU-LAIT SPOTS IN NEUROFIBROMATOSIS AND PIGMENTED MACULES OF NEVUS-SPILUS
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DOI：
10.1620/tjem.118.255
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发表时间：
1976-01-01
影响因子：
2.2
通讯作者：
TAKAHASHI, M
中科院分区：
文献类型：
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作者：
TAKAHASHI, M
对14例日本神经纤维瘤病患者的咖啡Au lait斑和9例日本患者的斑痣进行了黑素细胞性质差异的研究。色素性皮损的黑素细胞数与周围正常皮肤相比，前者总是增多的，咖啡Au lait斑的黑素细胞数高于斑痣。14例神经纤维瘤病中仅6例可见巨色素颗粒，斑痣未见巨色素颗粒。在4 × 104紫外线照射后2天，ED_（50），色素性皮损周围正常皮肤和色素性皮损中黑素细胞数均增加，色素性皮损中黑素细胞数的增加率较低。电镜下，黑素细胞在咖啡Au Lait斑接受紫外线照射后，其细胞质中出现了各种变化：树突的发展，含有许多成熟的黑素体，细胞质空泡和线粒体的数量增加，高尔基体在其细胞质中的发展，一些致密体和自噬体黑素体复合体的外观。在斑痣中，也发生了同样的变化，但与咖啡Au Lait斑相比，变化较为温和。咖啡Au lait斑角质形成细胞中的黑素体倾向于聚集在细胞核周围形成黑素体复合物;而照射后斑痣角质形成细胞中的黑素体似乎是单个分散的。本文还讨论了这两种色素斑色素沉着的原因及黑素细胞对紫外线照射的不同反应。
Cafe au lait spots from 14 Japanese patients with neurofibromatosis and nevus spilus from 9 Japanese patients were subjected to studies on the differences in the nature of their melanocytes. When the number of melanocytes of the pigmented lesions was compared with that of the surrounding normal skin, the former was always increased and that of the cafe au lait spots was higher than that of nevus spilus. Giant pigment granules were recognized only in 6 patients out of 14 with neurofibromatosis but not in the nevus spilus. Two days after UV irradiation at 4 .times. ED50, the number of melanocytes was increased in both the surrounding normal skin and in the pigmented lesion, and the rates of increase were lower in the pigmented lesion. Under EM, melanocytes in cafe au lait spots which received UV light irradiation showed various changes in their cytoplasm; a development of dendrites containing many mature melanosomes, an increased number of cytoplasmic vacuoles and mitochondria, a development of Golgi apparatus in their cytoplasm, appearances of some dense-bodies and of autophagosomal melanosome-complexes. In nevus spilus, the same kind of changes occurred, but they were moderate compared with those developed in cafe au lait spots. Melanosomes in the keratinocytes of cafe au lait spots tended to come together around the nucleus and to form melanosome-complexes; while melanosomes in the keratinocytes of nevus spilus seemed to be singly dispersed after irradiation. The causative factors of the hyperpigmentation and the different reactivity of melanocytes against UV irradiation in these 2 pigmented macules were discussed.