Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making
Involvement of catecholamine neurotransmission in the rat anterior cingulate in effort-related decision making
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DOI：
10.1037/0735-7044.119.6.1687
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发表时间：
2005-12-01
影响因子：
1.9
通讯作者：
Hauber, W
中科院分区：
文献类型：
--
作者：
Schweimer, J;Saft, S;Hauber, W
本研究旨在探讨前扣带皮层（ACC）中的儿茶酚胺介导的信号是否有助于基于努力的决策。在T迷宫成本效益任务中，将6-羟基多巴胺或载体输注到ACC中后对大鼠进行测试，其中大鼠可以选择爬上障碍物以在一只手臂中获得高奖励，或者在没有障碍物的情况下跑进另一只手臂以获得低奖励。结果表明，6-羟基多巴胺的输注诱导的酪氨酸羟化酶阳性纤维在ACC. Different假损伤大鼠，6-羟基多巴胺损伤大鼠表现出减少的偏好高成本高回报的反应选项时，获得低回报的选择，很少的努力。因此，ACC中的儿茶酚胺介导的信号可以在基于努力的决策中发挥作用。
This study examined whether catecholamine-mediated signals in the anterior cingulate cortex (ACC) contribute to effort-based decision making. Rats were tested after 6-hydroxydopamine or vehicle infusions into the ACC in a T maze cost-benefit task in which the rats could choose either to climb a barrier to obtain a high reward in one arm or run into the other arm without a barrier to obtain a low reward. Results demonstrate that infusions of 6-hydroxydopamine induced a near total loss of tyrosine hydroxylase-positive fibers in the ACC. Unlike sham-lesioned rats, 6-hydroxydopamine-lesioned rats exhibited a reduced preference for the high-cost-high-reward response option when given the choice of obtaining a low reward with little effort. Thus, catecholamine-mediated signals in the ACC could play a role in effort-based decision making.