Facile synthesis of black phosphorus-Au nanocomposites for enhanced photothermal cancer therapy and surface-enhanced Raman scattering analysis
Facile synthesis of black phosphorus-Au nanocomposites for enhanced photothermal cancer therapy and surface-enhanced Raman scattering analysis
复制标题
轻松合成黑磷-Au纳米复合材料，用于增强光热癌症治疗和表面增强拉曼散射分析
DOI：
10.1039/c7bm00414a
复制
发表时间：
2017
影响因子：
6.6
通讯作者：
Guo Zhouyi
中科院分区：
文献类型：
--
作者：
Yang Guangcun;Liu Zhiming;Li Yi;Hou Yuqing;Fei Xixi;Su Chengkang;Wang Songmao;Zhuang Zhengfei;Guo Zhouyi
黑磷(BP)是一种新型的二维纳米材料，由于其优异的性能和在化学、物理、生物等各个领域的巨大潜力，近年来引起了人们的广泛关注。本研究采用一步合成的方法制备了负载Au纳米颗粒的BP纳米片(BP-Au NSS)。Au纳米结构不仅可以提高纳米复合材料的光热效率，而且使BP-Au NSS具有作为有效的表面增强拉曼散射(SERS)底物用于拉曼生物检测的潜力。以BP-Au-NSS为纳米试剂，在体内外进行了肿瘤光热治疗。在808 nm激光照射下，BP-Au纳米微球能够产生足够的热能杀死癌细胞，大部分荷瘤小鼠的移植瘤消失；BP-Au纳米微球比裸BP纳米片更有效。PTT效应也可以通过拉曼技术监测，这得益于BP-Au NSS的高SERS活性。SERS分析清楚地识别了PTT治疗前后乳腺肿瘤的分子指纹特征。BP-Au-NSS在生物医学领域具有广阔的应用前景。
Black phosphorus (BP), a new type of two-dimensional nanomaterial, has attracted crucial attention in recent years owing to its excellent properties and great potential in various chemical, physical, and biological fields. In this study, BP nanosheets loaded with Au nanoparticles (BP–Au NSs) are obtained by a one-step facile synthetic method. The Au nanostructures can not only enhance the photothermal efficiency of the nanocomposites, but also endow BP–Au NSs with the potential to act as effective surface-enhanced Raman scattering (SERS) substrates for Raman biodetection. Cancer photothermal therapy (PTT) has been carried out in vitro and in vivo using BP–Au NSs as nanoagents. Under irradiation by an 808 nm laser, BP–Au NSs are capable of producing sufficient hyperthermia to destroy cancer cells, and the transplanted tumors in most of the tumor-bearing mice disappeared; BP–Au NSs are more effective than bare BP nanosheets. The PTT effect can also be monitored by a Raman technique that benefits from the high SERS activity of the BP–Au NSs. The molecular fingerprint features of breast tumors before and after PTT treatment were clearly identified using SERS analysis. The theranostic applications of BP–Au NSs exhibit promising potential in biomedicine.