Palladium‐Catalyzed CH Oxidation of Isoquinoline N‐Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides
Palladium‐Catalyzed CH Oxidation of Isoquinoline N‐Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides
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DOI：
10.1002/adsc.201101009
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发表时间：
2012-07
影响因子：
5.4
通讯作者：
B. Yao;Ren‐Jie Song;Yan Liu;Yexiang Xie;Jin‐Heng Li;Meng-Ke Wang;Ri‐Yuan Tang;Xing‐Guo Zhang;Chen-Liang Deng
中科院分区：
文献类型：
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作者：
B. Yao;Ren‐Jie Song;Yan Liu;Yexiang Xie;Jin‐Heng Li;Meng-Ke Wang;Ri‐Yuan Tang;Xing‐Guo Zhang;Chen-Liang Deng
发展了一种新的钯催化异喹啉N-氧化物CH氧化反应，用于区域选择性合成取代异喹啉。该方法代表了使用二烷基亚砜作为用于构建1-烷基化异喹啉的烷基源的第一个实例。此外，异喹啉N-氧化物的区域选择性卤化也是成功的使用二卤代亚砜作为卤化物源。
A novel palladium-catalyzed CH oxidation of isoquinoline N-oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1-alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N-oxides is also successful using dihalo sulfoxides as the halide sources.