Pet-Compton system. Comparative evaluation with PET system using Monte Carlo simulation
Pet-Compton system. Comparative evaluation with PET system using Monte Carlo simulation
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佩特康普顿系统。
DOI：
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Lourdes Bolaños Pérez
中科院分区：
文献类型：
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作者：
Angelina Díaz García;Juan A Rubio Rodríguez;J. Morales;P. A. Dubois;Oscar Vela Morales;Eduardo Romeu;Carlos Willmott Zappacosta;Yamiel Abreu Alfonso;A. Fabelo;I. P. Hernández;Lourdes Bolaños Pérez
小动物的正电子发射断层扫描（PET）实际上已经达到了大约1 mm的空间分辨率，目前正在研究不同的方法来提高这种空间分辨率。其中一个将PET技术与康普顿相机相结合。本文提出了所谓的“PET-Compton”系统的概念，并利用Geant 4程序进行了Monte Carlo模拟，对PET和PET-Compton系统的空间分辨率和全局效率进行了比较评价。对由特定小动物PET扫描仪“Clear-PET”的LYSO-LuYAP替代探测器和基于CdZnTe半导体的康普顿探测器组成的PET-Compton系统进行了模拟。在模拟条件下研究了一组几乎同时发射正电子（e+）和γ量子的放射性核素，它们满足一定的选择标准，可能用于医学和生物学应用的PET-Compton系统。通过SSRB（Single Slide Rebinning）方法的解析重建，在PET-Compton系统中对所有被测核素都获得了上级的空间分辨率（~（22）Na源达到亚毫米级）。然而，通过模拟完成的该分析已经示出了在“PET-Compton”系统中有限的全局效率值（在10-5-10- 6%的量级），而不是在PET系统中已经实现的大约5·10- 1%的值。
Positron Emission Tomography (PET) in small animals has actually achieved spatial resolution round about 1 mm and currently there are under study different approaches to improve this spatial resolution. One of them combines PET technology with Compton cameras. This paper presents the idea of the so called “PET-Compton” systems and has included comparative evaluation of spatial resolution and global effi ciency in both PET and PET-Compton system by means of Monte Carlo simulations using Geant4 code. Simulation was done on a PET-Compton system made-up of LYSO-LuYAP scintillating detectors of particular small animal PET scanner named “Clear-PET” and for Compton detectors based on CdZnTe semiconductor. A group of radionuclides that emits a positron (e+) and γ quantum almost simultaneously and fulfi lls some selection criteria for their possible use in PET-Compton systems for medical and biological applications were studied under simulation conditions. By means of analytical reconstruction using SSRB (Single Slide Rebinning) method were obtained superior spatial resolution in PET-Compton system for all tested radionuclides (reaching sub-millimeter values of for 22Na source). However this analysis done by simulation have shown limited global effi ciency values in “PET-Compton” system (in the order of 10-5-10-6 %) instead of values around 5·10-1 % that have been achieved in PET system.
影响因子：
3.8
作者：
M. Singh
通讯作者：
M. Singh