The cost of opioid-related adverse drug events.
The cost of opioid-related adverse drug events.
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DOI：
10.3109/15360288.2014.938889
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发表时间：
2014-09-01
影响因子：
1.1
通讯作者：
Dasta, Joseph F
中科院分区：
文献类型：
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作者：
Kane-Gill, Sandra L;Rubin, Ellen C;Dasta, Joseph F
阿片类药物是疼痛管理的基石;然而，它们的使用与各种药物不良事件（ADE）相关，从恶心和呕吐到尿潴留和呼吸抑制。本综述的目的是描述与不同类型阿片类药物相关ADE相关的频率和成本，以更好地了解其经济影响。使用MEDLINE和EMBASE检索1946年至2013年12月期间发表在期刊上的研究。共审查了20篇文章。数据反映了阿片类药物相关ADE的巨大经济负担，导致住院费用高、住院时间延长和大量医疗资源使用。恶心、呕吐和便秘是常见的，住院患者和门诊患者的所有类型的疼痛（手术、非手术、癌症、非癌症）都会增加费用。鉴于阿片类药物相关ADE的巨大经济负担，预防而不是治疗可能是最有效的策略。
Opioids are the cornerstone of pain management; however, their use is associated with a variety of adverse drug events (ADEs) ranging from nausea and vomiting to urinary retention and respiratory depression. The purpose of this review is to describe the frequency and cost associated with different types of opioid-related ADEs to better understand their economic impact. A search of studies published in journals from 1946 to December, 2013, was conducted using MEDLINE and EMBASE. A total of 20 articles were reviewed. Data reflect a substantial economic burden of opioid-related ADEs resulting in high hospital costs, prolonged hospital stays, and substantial health care resource usage. Nausea, vomiting, and constipation are frequent and increased costs occur in all types of pain (surgical, nonsurgical, cancer, noncancer) in both inpatients and outpatients. Given the large economic burden of opioid-related ADEs, prevention rather than treatment may be the most effective strategy.