Is ACE Gene Polymorphism a Useful Marker for Diabetic Albuminuria in Japanese NIDDM Patients?
Is ACE Gene Polymorphism a Useful Marker for Diabetic Albuminuria in Japanese NIDDM Patients?
复制标题
ACE 基因多态性是日本 NIDDM 患者糖尿病蛋白尿的有用标志物吗？
DOI：
10.2337/diacare.19.12.1420
复制
发表时间：
1996
期刊：
影响因子：
16.2
通讯作者：
Y. Yajima
中科院分区：
文献类型：
--
作者：
S. Nakajima;T. Baba;Y. Yajima
目的研究日本NIDDM患者ACE基因插入/缺失（I/D）多态性与蛋白尿/蛋白尿的关系。研究设计和方法：共有142名日本NIDDM患者（89名男性，53名女性），已知糖尿病病程为14 ± 5（平均值± SD）年，年龄为56 ± 6岁，根据肾病分期分为三组：41名正常白蛋白尿患者，47名微量白蛋白尿患者，54名明显蛋白尿患者。三组在年龄、糖尿病病程和近期HbA 1c水平方面相似。结果：ACE基因DD、ID和II型的分布在三组之间没有差异（正常白蛋白尿患者中分别为10、46和44%;微量白蛋白尿患者中分别为13、53和34%;蛋白尿患者中分别为15、46和39%）。男性蛋白尿患者D等位基因频率略高于正常蛋白尿男性患者（45% vs.27%，X2 = 3.9，P < 0.05），而女性蛋白尿患者D等位基因频率低于正常蛋白尿女性患者（P < 0.05）。结论ACE基因的基因型是预测日本NIDDM患者肾病发展的一个临床有用的遗传标记，这些结果并不支持这一假设。但ACE基因D等位基因在男性患者肾病进展中的作用还有待观察。
OBJECTIVE We studied the relationship between an insertion/deletion (I/D) polymorphism in the ACE gene and albuminuria/proteinuria in Japanese NIDDM patients. RESEARCH DESIGN AND METHODS A total of 142 Japanese NIDDM patients (89 men, 53 women) with a known diabetes duration of 14 ± 5 (mean ± SD) years and an age of 56 ± 6 years were divided into three groups according to the stage of nephropathy: 41 patients with normoalbuminuria, 47 patients with microalbuminuria, and 54 with overt proteinuria. The three groups were similar in age, diabetes duration, and recent HbA1c level. RESULTS The distribution of DD, ID, and II genotypes of the ACE gene did not differ among the three groups (10, 46, and 44% in the normoalbuminuric patients; 13, 53, and 34% in the microalbuminuric patients; and 15, 46, and 39% in the proteinuric patients, respectively). Meanwhile, the frequency of the D allele in the proteinuric male patients was slightly higher than in the normoalbuminuric male patients (45 vs. 27%, X 2 = 3.9, P < 0.05), while the D allele frequency was nonsignificantly lower in the proteinuric female patients than in the normoalbuminuric female patients. CONCLUSION These results did not support the hypothesis that the genotype of the ACE gene would be a clinically useful genetic marker for predicting the development of nephropathy in Japanese NIDDM patients. However, the role of D allele of ACE gene in the progression of nephropathy in male patients remains to be seen.