Parallel processing by distinct classes of principal neurons in the olfactory cortex.
Parallel processing by distinct classes of principal neurons in the olfactory cortex.
复制标题
嗅觉皮层中不同类主神经元的并行处理。
DOI：
10.7554/elife.73668
复制
发表时间：
2021-12-16
期刊：
影响因子：
7.7
通讯作者：
Franks KM
中科院分区：
文献类型：
--
作者：
Nagappan S;Franks KM
了解神经回路中不同类型的神经元如何处理和传播信息对于理解回路的功能以及如何完成任务至关重要。嗅觉（梨状，PCx）皮层包含两种主要类型的主神经元，半月（SL）和浅锥体（PYR）细胞。SL和PYR具有不同的形态、局部连通性、生物物理特性和下游投射靶点。PCx中的气味处理被认为发生在两个连续的阶段。首先，SL接收并整合嗅球输入，然后PYR接收、转换并传输SL输入。为了测试该模型，我们记录了清醒的头部固定小鼠中的光遗传学鉴定的SL和PYR群体。值得注意的是，沉默SL并没有改变PYR气味反应，SL和PYR表现出气味调谐特性和反应辨别力的差异，这与它们在感觉-联想皮层内的不同嵌入是一致的。因此，我们的研究结果表明，SL和PYR形成并行通道，差异处理气味信息，并通过PCx。
Understanding how distinct neuron types in a neural circuit process and propagate information is essential for understanding what the circuit does and how it does it. The olfactory (piriform, PCx) cortex contains two main types of principal neurons, semilunar (SL) and superficial pyramidal (PYR) cells. SLs and PYRs have distinct morphologies, local connectivity, biophysical properties, and downstream projection targets. Odor processing in PCx is thought to occur in two sequential stages. First, SLs receive and integrate olfactory bulb input and then PYRs receive, transform, and transmit SL input. To test this model, we recorded from populations of optogenetically identified SLs and PYRs in awake, head-fixed mice. Notably, silencing SLs did not alter PYR odor responses, and SLs and PYRs exhibited differences in odor tuning properties and response discriminability that were consistent with their distinct embeddings within a sensory-associative cortex. Our results therefore suggest that SLs and PYRs form parallel channels for differentially processing odor information in and through PCx.