Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
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DOI：
10.3390/ma5091661
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发表时间：
2012-09-17
期刊：
影响因子：
3.4
通讯作者：
Chang TS
中科院分区：
文献类型：
--
作者：
Chang TS
黑素生成是人类皮肤形成黑色素的生物合成途径。酪氨酸酶是黑素合成的第一个也是唯一一个限速步骤，下调酶活性是目前报道最多的抑制黑素合成的方法。由于色素沉着这一美容方面的重要问题，对黑素生成抑制剂的需求很大。这鼓励研究人员寻找有效的黑色素生成抑制剂用于化妆品。本文综述了最近从天然来源发现的黑素生成抑制剂。并对抑制剂对酪氨酸酶活性的作用机理进行了讨论。
Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed.