Perspectives and concerns regarding antimicrobial agent shortages among infectious disease specialists
Perspectives and concerns regarding antimicrobial agent shortages among infectious disease specialists
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DOI：
10.1016/j.diagmicrobio.2012.11.020
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发表时间：
2013-03-01
影响因子：
2.9
通讯作者：
Polgreen, Philip M.
中科院分区：
文献类型：
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作者：
Gundlapalli, Adi V.;Beekmann, Susan E.;Polgreen, Philip M.
抗菌药物的短缺使得治疗某些感染变得更加困难。 2011 年，美国传染病学会新兴传染病网络的 1328 名传染病医生成员收到了一份关于抗菌药物短缺经历的网络调查。 627 名受访者中的大多数 (78%) 表示，由于过去 2 年内药物短缺，需要改变抗菌药物的选择。最常报告为无法获得或可获得但供应短缺的抗菌药物是甲氧苄氨嘧啶-磺胺甲恶唑注射液（65% 的受访者）、阿米卡星（58%）、氨曲南（31%）和膦甲酸（22%）。大多数报告短缺的受访者（55%）表示，短缺对患者的治疗结果产生了不利影响，他们被迫使用替代药物和二线药物，这些药物要么效果较差，毒性更大，要么成本更高。大多数人（70%）表示，他们是在尝试开出供应短缺的药物后，通过与药房联系才得知短缺的。更有效地向医生通报药品短缺情况对于减少对患者护理的影响至关重要。由爱思唯尔公司出版
Antimicrobial shortages have made treating certain infections more difficult. A web-based survey asking about experience with antimicrobial drug shortages was distributed in 2011 to 1328 infectious diseases physician members of the Emerging Infectious Diseases Network of the Infectious Diseases Society of America. A majority (78%) of 627 respondents reported needing to modify antimicrobial choices because of drug shortages within the past 2 years. Antimicrobials most often reported as not available or available but in short supply were trimethoprim-sulfamethoxazole injection (by 65% of respondents), amikacin (by 58%), aztreonam (by 31%), and foscarnet (by 22%). Most respondents (55%) reporting a shortage indicated that the shortage adversely affected patient outcomes and that they were forced to use alternative and second line agents which were either less effective, more toxic, or more costly. Most (70%) indicated that they learned about the shortage from contact with the pharmacy after trying to prescribe a drug in short supply. More effective means of informing physicians about drug shortages is critical to lessen the impact on patient care. Published by Elsevier Inc.