Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
Could Positive Feedback Enable Bacterial Pheromone Signaling To Coordinate Behaviors in Response to Heterogeneous Environmental Cues?
复制标题
DOI：
10.1128/mbio.00098-18
复制
发表时间：
2018-05-15
期刊：
影响因子：
6.4
通讯作者：
Stabb EV
中科院分区：
文献类型：
--
作者：
Stabb EV
信息素信号传导（PS）是许多重要细菌行为的基础，但其生态功能仍未得到解决。由于信息素介导的行为需要高细胞密度，因此术语“群体感应”被广泛用于描述和理解 PS。然而，虽然这个术语已经统一并普及了该领域，但细菌 PS 显然具有超出人口普查的作用，并且 PS 电路的复杂性表明其具有更广泛的功能。细菌 PS 的两个共同特征是其对环境条件的调节和正反馈循环。结合起来，这些可以使 PS 协调依赖于群体的群体行为，以响应异质环境线索。特别是在正反馈很强的 PS 系统中，距离刺激环境相对较远的细胞可以被招募到群体反应中。测试该模型将受益于在异质环境中对不同群体的细胞中的相关环境线索和 PS 输出进行原位检查，无论是否有正反馈。
Pheromone signaling (PS) underlies many important bacterial behaviors, yet its ecological functions remain unresolved. Because pheromone-mediated behaviors require high cell density, the term “quorum sensing” is widely used to describe and make sense of PS. However, while this term has unified and popularized the field, bacterial PS clearly has roles beyond census taking, and the complexities of PS circuits indicate broader functional capacities. Two common features of bacterial PS are its regulation in response to environmental conditions and positive-feedback loops. Combined, these could enable PS to coordinate quorum-dependent group behaviors in response to heterogeneous environmental cues. Particularly in PS systems where positive feedback is strong, cells that are relatively far from a stimulatory environment could be recruited to a group response. Testing this model will benefit from in situ examination of relevant environmental cues and PS outputs in cells across populations, with and without positive feedback, in heterogeneous environments.