Modeled prenatal exposure to per- and polyfluoroalkyl substances in association with child autism spectrum disorder: A case-control study.
Modeled prenatal exposure to per- and polyfluoroalkyl substances in association with child autism spectrum disorder: A case-control study.
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DOI：
10.1016/j.envres.2020.109514
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发表时间：
2020-04
影响因子：
8.3
通讯作者：
Hyeong-Moo Shin;D. Bennett;A. Calafat;D. Tancredi;I. Hertz-Picciotto
中科院分区：
文献类型：
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作者：
Hyeong-Moo Shin;D. Bennett;A. Calafat;D. Tancredi;I. Hertz-Picciotto
背景/目的多氟烷基物质(PFAS)在实验动物研究中表现出神经行为毒性。我们检验了模拟的产前母亲接触PFAS与儿童孤独症谱系障碍(ASD)诊断的关系。方法研究对象为453对来自CHILDHOOD AUTISM Risk from the Genetics and Environment的母子，这是一项基于人群的病例对照研究。儿童接受心理测试，并经临床证实患有自闭症(n=239)或典型发育障碍(n=2214)。在门诊结束时，采集母亲的血液样本。我们量化了9个在孩子2-5岁时收集的母体血清样本中的全氟辛烷磺酸。作为宫内暴露的代用品，我们使用了一个由孕期和产后24个月的外部预期数据建立的模型，然后在这个病例对照样本中重建了孕期孕妇的PFAS血清浓度。结果模拟的产前孕妇全氟己烷磺酸盐(PFHxS)和全氟辛烷磺酸(PFOS)与儿童ASD的诊断几率增加(每毫升增加：优势比[OR]=1.46；95%可信区间[CI]：PFHxS：0.98，2.18，OR=1.03；95%CI：0.99，1.08)。与最低四分位数(参考类别)相比，产前建模母亲PFHxS的最高四分位数与儿童诊断ASD的几率增加相关(OR=1.95；95%CI：1.02，3.72)。结论在将产前孕妇的PFAS血清浓度作为宫内暴露的分析中，我们观察到产前PFHxS和PFOS暴露与儿童诊断ASD的几率增加密切相关，但与其他PFAS无关。需要进一步的研究，前瞻性地测量处于不同发育阶段的母亲和儿童的全氟辛烷磺酸浓度，以证实这些发现。
Background/objectivePer- and polyfluoroalkyl substances (PFAS) display neurobehavioral toxicity in laboratory animal studies. We examined associations of modeled prenatal maternal exposure to PFAS with child diagnosis of autism spectrum disorder (ASD).MethodsParticipants were 453 mother-child pairs from CHARGE (CHildhoodAutismRisk fromGenetics andEnvironment), a population-based case-control study. Children underwent psychometric testing and were clinically confirmed for ASD (n= 239) or typical development (TD,n= 214). At the end of the clinic visit, maternal blood specimens were collected. We quantified nine PFAS in maternal serum samples collected when their child was 2–5 years old. As surrogate in utero exposure, we used a model built from external prospective data in pregnancy and 24 months post-partum and then reconstructed maternal PFAS serum concentrations during pregnancy in this case-control sample. We used logistic regression to evaluate associations of modeled prenatal maternal PFAS concentrations with child ASD.ResultsModeled prenatal maternal perfluorohexane sulfonate (PFHxS) and perfluorooctane sulfonate (PFOS) were borderline associated with increased odds of child diagnosis of ASD (per nanogram per milliliter increase: odds ratio [OR] = 1.46; 95% confidence interval [CI]: 0.98, 2.18 for PFHxS, OR = 1.03; 95% CI: 0.99, 1.08 for PFOS). When compared to the lowest quartile (reference category), the highest quartile of modeled prenatal maternal PFHxS was associated with increased odds of child diagnosis of ASD (OR = 1.95; 95% CI: 1.02, 3.72).ConclusionsIn analyses where modeled prenatal maternal PFAS serum concentrations served as in utero exposure, we observed that prenatal PFHxS and PFOS exposure, but not other PFAS, were borderline associated with increased odds of child diagnosis of ASD. Further studies in which PFAS concentrations are prospectively measured in mothers and children at a range of developmental stages are needed to confirm these findings.