Hepcidin-25 Concentrations Are Markedly Increased in Patients With Chronic Kidney Disease and Are Inversely Correlated With Estimated Glomerular Filtration Rates
Hepcidin-25 Concentrations Are Markedly Increased in Patients With Chronic Kidney Disease and Are Inversely Correlated With Estimated Glomerular Filtration Rates
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DOI：
10.1002/jcla.21634
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Konrad, Robert J.
中科院分区：
文献类型：
--
作者：
Troutt, Jason S.;Butterfield, Anthony M.;Konrad, Robert J.
背景Hepcidin-25 通过结合铁转运蛋白铁转运蛋白并导致其降解来调节铁稳态。 hepcidin-25 增加会导致肠道铁吸收和细胞内铁储存释放减少。我们在这项研究中的目的是测量慢性肾病 (CKD) 患者的 hepcidin-25 水平，以确定它们是否可能导致 CKD 贫血。方法我们使用 hepcidin-25 特异性酶联免疫吸附测定法来测量 103 名 CKD 患者和 100 名健康个体的 hepcidin-25。我们在 CKD 受试者中评估了 Hepcidin-25 与肌酐、估计肾小球滤过率 (eGFR)、血红蛋白、血尿素氮、血清铁、转铁蛋白和铁蛋白的相关性。 结果与健康受试者相比，CKD 患者中 Hepcidin-25 浓度显着升高（60.4±6.1 g/l vs. 3.0 +/- 0.5 g/l，P < 0.001）。 Hepcidin-25 浓度与肌酐直接相关（R = 0.28，P = 0.004），与 eGFR 呈负相关（R = -0.32，P = 0.001）。 Hepcidin-25 水平还与转铁蛋白（R = -0.28，P = 0.004）和铁蛋白（R = 0.80，P < 0.001）相关。 结论 Hepcidin-25 与肌酐正相关，与 eGFR 负相关，提示随着肾功能恶化，hepcidin-25 水平升高，可能是由于 hepcidin-25 肾清除率降低所致。
BackgroundHepcidin-25 regulates iron homeostasis by binding the iron transporter ferroportin, causing its degradation. Increased hepcidin-25 causes decreased intestinal iron absorption and release from intracellular stores. Our objective in this study was to measure hepcidin-25 levels in patients with chronic kidney disease (CKD) to determine if they might contribute to the anemia of CKD.MethodsWe used a hepcidin-25-specific enzyme-linked immunosorbent assay to measure hepcidin-25 in 103 CKD patients and 100 healthy individuals. We assessed in CKD subjects the correlation of hepcidin-25 with creatinine, estimated glomerular filtration rate (eGFR), hemoglobin, blood urea nitrogen, serum iron, transferrin, and ferritin.ResultsHepcidin-25 concentrations in CKD patients were significantly increased compared to healthy subjects (60.4 6.1 g/l vs. 3.0 +/- 0.5 g/l, P < 0.001). Hepcidin-25 concentrations were directly correlated with creatinine (R = 0.28, P = 0.004) and inversely correlated with eGFR (R = -0.32, P = 0.001). Hepcidin-25 levels were also correlated with transferrin (R = -0.28, P = 0.004) and ferritin (R = 0.80, P < 0.001).ConclusionThe direct correlation of hepcidin-25 with creatinine and its inverse correlation with eGFR suggest that hepcidin-25 levels increase as renal function deteriorates, possibly due to decreased hepcidin-25 renal clearance.