Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
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DOI：
10.1016/s1534-5807(01)00059-4
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发表时间：
2001-10-01
影响因子：
11.8
通讯作者：
Hoffmann, JA
中科院分区：
文献类型：
--
作者：
Georgel, P;Naitza, S;Hoffmann, JA
我们报告的免疫缺陷（imd）基因，控制果蝇抗菌防御的分子特征。imd编码具有与哺乳动物RIP（受体相互作用蛋白）相似的死亡结构域的蛋白，RIP是在NF-κ B活化和凋亡中起作用的蛋白。我们发现，imd的功能上游的DmIKK信号体和半胱天冬酶DREDD的抗菌肽基因的控制。引人注目的是，imd的过度表达导致这些基因的组成性转录和细胞凋亡，这两种作用都被半胱天冬酶抑制剂P35的共表达所阻断。我们还表明，imd参与了紫外线照射的凋亡反应。这些数据提出了抗菌反应和细胞凋亡在果蝇中共享共同控制元件的可能性。
We report the molecular characterization of the immune deficiency (imd) gene, which controls antibacterial defense in Drosophila. imd encodes a protein with a death domain similar to that of mammalian RIP (receptor interacting protein), a protein that plays a role in both NF-kappaB activation and apoptosis. We show that imd functions upstream of the DmIKK signalosome and the caspase DREDD in the control of antibacterial peptide genes. Strikingly, overexpression of imd leads to constitutive transcription of these genes and to apoptosis, and both effects are blocked by coexpression of the caspase inhibitor P35. We also show that imd is involved in the apoptotic response to UV irradiation. These data raise the possibility that antibacterial response and apoptosis share common control elements in Drosophila.