Absence of Hypoalbuminemia Despite Nephrotic Proteinuria in Focal Segmental Glomerulosclerosis Secondary to Polycythemia Vera
Absence of Hypoalbuminemia Despite Nephrotic Proteinuria in Focal Segmental Glomerulosclerosis Secondary to Polycythemia Vera
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DOI：
10.2169/internalmedicine.49.4087
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发表时间：
2010-01-01
影响因子：
1.2
通讯作者：
Kazaz, Nazli
中科院分区：
文献类型：
--
作者：
Ulusoy, Sukru;Ozkan, Gulsum;Kazaz, Nazli
除了显示地理差异，局灶节段性肾小球硬化症（FSGS）已成为近年来成人肾病综合征的最常见原因。当肾小球工作负荷增加时，特别是观察到继发性FSGS。真性红细胞增多症（PV）是一种以红系异常增殖为特征的血液病。属于继发于PV的肾小球肾炎的病例报告数量有限。在文献中，很少有FSGS的报道。一项研究指出，当存在肾病蛋白尿时，在继发于超滤的FSGS患者中检测到正常白蛋白血症。在此，我们报告一个FSGS的病例，尽管继发于PV的肾病范围蛋白尿发展为正常白蛋白血症。本例为文献中首次报道。
In addition to displaying geographic variation, focal segmental glomerulosclerosis (FSGS) has become the commonest cause of the nephrotic syndrome seen in adults in recent years. Secondary FSGS in particular, is observed when glomerular workload is increased. Polycythemia vera (PV) is a hematological disease characterized by abnormal proliferation in the erythroid series. The number of case reports belonging to glomerulonephritis secondary to PV is limited. In the literature, there are few reports of FSGS. One study pointed out that the presence of normoalbuminemia was detected in patients with FSGS secondary to hyperfiltration when there was nephrotic proteinuria. Here, we report a case of FSGS following a course with normoalbuminemia despite nephrotic range proteinuria developing secondary to PV. Our case is the first report in the literature with thes characteristics.