Naturally occurring tumors in dogs as comparative models for cancer therapy research.
Naturally occurring tumors in dogs as comparative models for cancer therapy research.
复制标题
狗体内自然发生的肿瘤作为癌症治疗研究的比较模型。
作者：
Kevin A. Hahn;L. Bravo;W. Adams;D. Frazier
在癌症治疗研究中，美国宠物数量一直是一个未得到充分利用的资源。狗的自然发生肿瘤的发展速度是人类的两倍，具有与人类肿瘤相似的组织病理学特征和生物学行为，并且进展速度比人类更快。癌症是人类和狗的主要死因之一。可用于比较治疗研究的犬类恶性肿瘤包括淋巴瘤、乳腺肿瘤、口腔黑色素瘤、肺癌、鼻部肿瘤、软组织肉瘤和骨肉瘤。这份报告将讨论这些恶性肿瘤的比较性质和临床癌症研究的当前趋势，即使用客户拥有的狗身上自然发生的肿瘤进行剂量强化和生物调节。
The United States pet population has been a vastly underutilized resource for cancer therapy studies. Naturally occurring tumors in dogs develop twice as frequently as in man, have histopathologic features and a biologic behavior similar to tumors in man, and progress at a more rapid rate than in man. Cancer is one of the leading causes of death in man and dogs. The canine malignancies that are of practical use for comparative therapeutic studies include lymphoma, mammary tumors, oral melanoma, lung tumors, nasal tumors, soft tissue sarcomas, and osteosarcoma. This report will discuss the comparative nature of these malignancies and the current trends in clinical cancer research, namely dose intensification and biomodulation, using naturally occurring tumors in client-owned dogs.