Natural killer cell response to regional lymph node metastases.
Natural killer cell response to regional lymph node metastases.
复制标题
自然杀伤细胞对区域淋巴结转移的反应。
DOI：
10.1001/archotol.1986.03780050069012
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
L. Poisson
中科院分区：
文献类型：
--
作者：
S. Schantz;L. Poisson
对67例晚期头颈癌患者进行了自然杀伤细胞活性测定。28例临床分期为T3NO或T4NO的患者的平均活性为81+/-11个裂解单位(LU)，显著高于39例可触及的淋巴结转移者(54+/-5LU)。通过对患者结节病变程度的评估发现，随着N分期的进展，活动实际上增加了，尽管不是很明显。在有淋巴结转移的患者中，自然杀伤细胞细胞毒性增加的一个主要决定因素是颈部结外癌。9例肿瘤被固定在下层结构或粘连在皮肤上的患者的平均活度为87+/-15LU，显著高于其余临床确定的区域性结节疾病患者的45+/-4LU。对这些发现的潜在临床意义进行了讨论。
A determination of natural killer cell activity was performed in 67 individuals with advanced head and neck cancer. The mean activity of 28 patients clinically staged T3 NO or T4 NO was 81 +/- 11 lytic units (LU), significantly higher than 39 patients with palpable lymph node metastases (54 +/- 5 LU). Assessing patients by extent of nodal disease revealed that activity actually increased, though not significantly, with progressive N-staging. A major determinate of increased natural killer cell cytotoxicity in patients with lymph node metastases was extranodal cancer within the neck. The mean activity of nine patients whose tumor was fixed to underlying structures or adherent to skin was 87 +/- 15 LU, significantly higher than the 45 +/- 4 LU mean value of the remaining patients with clinically determined regional nodal disease. The potential clinical implications of these findings are discussed.
人肺癌和恶性黑色素瘤中自然杀伤细胞活性和干扰素反应的缺陷。
影响因子：
11.2
作者：
SibbittJr,WL;Bankhurst,AD;Jumonville,AJ;Saiki,JH;Saiers,JH;Doberneck,RC
通讯作者：
Doberneck,RC
人类癌症中的自然细胞毒性和干扰素产生：晚期疾病患者自然杀伤活性不足，干扰素产生正常。
DOI：
--
发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kadish,AS;Doyle,AT;Steinhauer,EH;Ghossein,NA
通讯作者：
Ghossein,NA