Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice
Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice
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DOI：
10.1016/j.neulet.2006.05.004
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发表时间：
2006-08-07
影响因子：
2.5
通讯作者：
Hu, Gang
中科院分区：
文献类型：
--
作者：
Li, Zhen;Gao, Lin;Hu, Gang
Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface. It has been reported that AQP4 deletion results in an increase of amino acid and monoamine levels in some brain regions of mice, suggesting that AQP4 may participate in region-specific alterations in brain amino acid and monoamine metabolism.在本研究中，我们检查了 AQP4 是否影响急性和慢性可卡因暴露小鼠的神经传递。为此，使用野生型和 AQP4 敲除小鼠进行运动活性评估和微透析方法。 The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine. Therefore, AQP4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn AQP4 deletion may attenuate cocaine reinforcement and dependence. (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Aquaporin-4 (AQP4) is the predominant water channel of brain, which mediates transmembrane water movement at the blood-brain barrier and at the brain-cerebrospinal fluid interface. It has been reported that AQP4 deletion results in an increase of amino acid and monoamine levels in some brain regions of mice, suggesting that AQP4 may participate in region-specific alterations in brain amino acid and monoamine metabolism. In the present study, we examined whether AQP4 affects neurotransmission in acute and chronic cocaine exposure mice. For this purpose, both wild-type and AQP4 knockout mice were used with locomotor activity evaluation and microdialysis methods. The results reveal that AQP4 deletion attenuated locomotor activity in acute and repeated cocaine exposure mice, and induced a decrease of extracellular dopamine and glutamate levels in the nucleus accumbens (NAc), a brain region known to be critically involved in the addictive properties of cocaine. Therefore, AQP4 may play a role in regulating extracellular cocaine-induced dopamine and glutamate release in the brain reward center, and in turn AQP4 deletion may attenuate cocaine reinforcement and dependence. (c) 2006 Elsevier Ireland Ltd. All rights reserved.