PREVALENCE OF ALZHEIMERS-DISEASE IN A COMMUNITY POPULATION OF OLDER PERSONS - HIGHER THAN PREVIOUSLY REPORTED
PREVALENCE OF ALZHEIMERS-DISEASE IN A COMMUNITY POPULATION OF OLDER PERSONS - HIGHER THAN PREVIOUSLY REPORTED
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DOI：
10.1001/jama.1989.03430180093036
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发表时间：
1989-11-10
影响因子：
120.7
通讯作者：
TAYLOR, JO
中科院分区：
文献类型：
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作者：
EVANS, DA;FUNKENSTEIN, H;TAYLOR, JO
在美国一个地理区域明确的社区中，对临床确诊的阿尔茨海默病及其他痴呆疾病进行了评估。在3623人（占该社区所有65岁以上居民的80.8%）在家中接受了简短的记忆测试后，其中467人的分层样本接受了神经学、神经心理学和实验室检查。根据接受临床评估的样本计算出该社区人群的阿尔茨海默病患病率。在65岁以上的人群中，估计有10.3%（95%置信区间为8.1% - 12.5%）可能患有阿尔茨海默病。该患病率与年龄密切相关。在65 - 74岁的人群中，3.0%（95%置信区间为0.8% - 5.2%）可能患有阿尔茨海默病，而在75 - 84岁的人群中这一比例为18.7%（95%置信区间为13.2% - 24.2%），在85岁以上的人群中则为47.2%（95%置信区间为37.0% - 63.2%）。其他痴呆病症并不常见。在有中度或重度认知障碍的社区居民中，84.1%临床上确诊为阿尔茨海默病且为唯一可能的诊断。这些数据表明，临床确诊的阿尔茨海默病是一种常见疾病，并且随着人口寿命的延长，其对公共卫生的影响将持续增加。
Clinically diagnosed Alzheimer''s disease and other dementing illnesses were assessed in a georaphically defined US community. Of 3623 persons (80.8% of all community residents over 65 years of age) who had brief memory testing in their homes, a stratified sample of 467 persons underwent neurological, neuropsychological, and labortory examination. Prevalence rates of Alzheimer''s disease were calculated for the community population from the sample undergoing clinical evaluation. Of those over the age of 65 years, and estimated 10.3% (95% confidence limits, 8.1% and 12.5%) had probable Alzheimer''s disease. This prevalence rate was strongly associated with age. Of those 65 to 74 years old, 3.0% (95% confidence limits, 0.8 and 5.2) had probable Alzheimer''s disease, compared with 18.7% (95% confidence limits, 13.2 and 24.2) of those 75 to 84 years old and 47.2% (95% confidence limits, 37.0 and 63.2) of those over 85 years. Other dementing conditions were uncommon. Of community residents with moderate or severe cognitive impairment, 84.1% had clinically diagnosed Alzheimer''s disease as the only probable diagnosis. These data suggest that clinically diagnosed Alzheimer''s disease is a common condition and that its public health impact will continue to increase with increasing longevity of the population.