Studies on the NMR spectroscopic properties of gelsemine--revisions and refinements.
Studies on the NMR spectroscopic properties of gelsemine--revisions and refinements.
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DOI：
10.1021/np50042a016
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发表时间：
1985-11
影响因子：
5.1
通讯作者：
Y. Schun;G. Cordell
中科院分区：
文献类型：
--
作者：
Y. Schun;G. Cordell
虽然大多数作业在！h -和13c -核磁共振谱（表1）与之前得到的结果（11,12）比较有利，但发现有必要进行一些修订。图1显示了凝胶胺在1.9-4.1 ppm范围内的同核二维相关谱。原来的H-l4a、H-l4e、H-15、h - 16的作业显然需要修改。因此，2.43 ppm的信号现在可以归因于H-16，而不是H-l4a，因为它是唯一与H-17亚甲基质子偶联的质子。因此，37.93 ppm的信号现在可以归因于C-16。C-14的轴向质子，与两个H-3偶联
Although most of the assignments in the! H-and 13C-nmr spectra (Table 1) com-pare favorably with those derived earlier (11, 12), a number of revisions were found to be necessary. Figure 1 shows the homonuclear 2-D correlation spectrum of gelsemine in the range 1.9-4.1 ppm. It is clear that the original assignments for H-l4a, H-l4e and H-15 and H-l6 should be revised. Thus, the signal at 2.43 ppm can now be attributed to H-16, rather than H-l4a, since it is the only proton with coupling to the H-17 methylene protons. Consequently, the signal at 37.93 ppm could now be ascribed to C-16. The axial proton at C-14, coupling to both H-3