Cerebrospinal Tau, Phospho-Tau, and Beta-Amyloid and Neuropsychological Functions in Parkinson's Disease
Cerebrospinal Tau, Phospho-Tau, and Beta-Amyloid and Neuropsychological Functions in Parkinson's Disease
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DOI：
10.1002/mds.22594
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发表时间：
2009-11-15
影响因子：
8.6
通讯作者：
Tolosa, Eduardo
中科院分区：
文献类型：
--
作者：
Compta, Yaroslau;Marti, Maria J.;Tolosa, Eduardo
阿尔茨海默病（AD）病理可能在帕金森病（PD）相关痴呆（PDD）中发挥作用。本研究的目的是评估脑脊液（CSF）中tau、phospho-tau和β -淀粉样蛋白（AD生物标志物）的水平，以及它们与PD患者认知功能的关系。PD患者40例[无痴呆（pnd） 20例；20名PDD患者和30名对照组使用特异性ELISA技术对CSF tau、磷酸化tau和β -淀粉样蛋白进行分析。所有PD患者和15名对照者接受额皮质下（注意力、流畅性）和新皮质（记忆、命名、视觉）功能的神经心理学测试。比较各组间脑脊液标志物水平，并分别与pnd和PDD的神经心理学指标进行比较和相关。PDD组脑脊液tau和磷酸化tau高于pnd组和对照组（P < 0.05）。脑脊液β -淀粉样蛋白水平从高（对照组）到中（PDD）和低（PDD）不等（P < 0.001）。在所有PD和PDD患者中，高CSF tau和磷酸化tau与记忆和命名障碍有关。在pnd中，脑脊液β -淀粉样蛋白与语音流畅性有关。这些发现表明PDD的潜在ad病理与皮质认知功能障碍有关，并且PDD语音流畅性受损患者脑脊液β -淀粉样蛋白水平低是认知功能障碍的早期标志。(C) 2009运动障碍学会
Alzheimer's disease (AD)-pathology may play a role in Parkinson's disease (PD)-related dementia (PDD). The aim of this study was to assess cerebrospinal fluid (CSF) levels of tau, phospho-tau, and beta-amyloid, proposed AD biomarkers, and their relationship with cognitive function in PD. Forty PD patients [20 nondemented (PDND); 20 PDD] and 30 controls underwent CSF tau, phospho-tau, and beta-amyloid analysis using specific ELISA techniques. All PD patients and 15 controls underwent neuropsychological testing of fronto-subcortical (attention, fluency) and neocortical (memory, naming, visuoperceptive) functions. CSF markers levels were compared between groups, and compared and correlated with neuropsychological measures in PDND and PDD separately and as a continuum (PD). CSF tau and phospho-tau were higher in PDD than in PDND and controls (P < 0.05). CSF beta-amyloid ranged from high (controls) to intermediate (PDND) and low (PDD) levels (P < 0.001). In all PD and PDD patients, high CSF tau and phospho-tau were associated with impaired memory and naming. In PDND, CSF beta-amyloid was related with phonetic fluency. These findings suggest underlying AD-pathology in PDD in association with cortical cognitive dysfunction, and that low CSF beta-amyloid in PDND patients with impaired phonetic fluency call constitute ail early marker of cognitive dysfunction. (C) 2009 Movement Disorder Society