HLA and longevity.
HLA and longevity.
复制标题
HLA 与长寿。
作者：
J. Proust;R. Moulias;Frédéric Fumeron;F. Bekkhoucha;Marc Busson;Michael C. Schmid;Jacques Hors
对 155 名健康九旬老人（45 名男性和 100 名女性）（均为法国白种人）进行了 HLA 复合体 A、B、C、DR 基因座等位基因的表型分析。将观察到的 HLA 抗原频率与年龄范围为 10 至 50 岁的 133 名男性和 179 名女性的对照系列进行比较。当比较整个年轻人和老年人系列时，在任何位点的 HLA 抗原分布或杂合性方面均未观察到显着差异。然而，当考虑到性别差异时，在老年女性组中发现了过量的 Cw1 抗原（p 小于 0.001），在老年男性组中发现了过量的 Cw7 抗原（p 小于 0.001）。特别重要的是，在这种情况下，Cw7 属于表型组合（最有可能属于相应的单倍型）A1/Cw7/B8/DR3，发现该组合在男性九十多岁时显着增加（p 小于 0.001）。这些结果支持以下假设：某些 HLA 单倍型与生存优势相关。
One hundred fifty-five healthy nonagenarians, 45 men and 100 women, all French Caucasians, were phenotyped for alleles of the A, B, C, DR loci of the HLA complex. The observed HLA antigen frequencies were compared to those of a control series of 133 males and 179 females whose ages ranged from 10 to 50 years. When comparing the total young and elderly series, no significant differences were observed with respect to HLA antigen distribution or heterozygosity at any of the loci. When taking sex difference into account, however, an excess of the Cw1 antigen was found in the group of elderly females (p less than 0.001) and an excess of the Cw7 antigen in the group of elderly males (p less than 0.001). Of particular significance was the fact that Cw7 belonged in this instance to a phenotypic combination (and most probably to the corresponding haplotype) A1/Cw7/B8/DR3 which was found significantly increased in male nonagenarians (p less than 0.001). These results support the hypothesis that certain HLA haplotypes are associated with survival advantage.