Cardiovascular effects and pharmacokinetics of the carboxylic ionophore monensin in dogs and rabbits.
Cardiovascular effects and pharmacokinetics of the carboxylic ionophore monensin in dogs and rabbits.
复制标题
羧基离子载体莫能菌素对狗和兔子的心血管作用和药代动力学。
DOI：
10.1016/0024-3205(81)90604-4
复制
发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Pressman,BC
中科院分区：
文献类型：
--
作者：
Fahim,M;Pressman,BC
戊巴比妥麻醉犬静脉注射（100 μg/kg）莫能菌素或清醒犬口服（2 mg/kg）莫能菌素能产生强降压、正性变时作用，并能提高血糖水平。静脉给药莫能菌素以约2.5分钟的时间迅速从血液中消失，在清醒的狗中，摄入莫能菌素在喂食后90分钟出现血浆水平峰值；这与动脉血压和血糖的最大升高时间一致。在清醒的家兔中，尽管给予了更高剂量的莫能菌素，静脉注射200 μg/kg和口服10 mg/kg，但其心血管作用比在狗中观察到的要小，并且起效较慢。这与注射莫能菌素从血液中清除较慢（t 12 = 8分钟）和摄入莫能菌素从肠道进入血液较慢有关。兔口服莫能菌素后17小时血浆和组织水平高于口服莫能菌素后6小时。
Monensin, a carboxylic ionophore, produces strong pressor, positive chronotropic effects and elevates the blood glucose level when injected intravenously (100 μg/kg) into pentobarbital anesthetized dogs or administered orally (2 mg/kg) to conscious dogs. Intravenously administered monensin disappeared from the blood rapidly with a t 1 2 of ca. 2.5 min and, in the conscious dogs, ingested monensin showed a peak plasma level 90 min after feeding; this coincided with the time of maximum increase in arterial blood pressure and blood glucose. In conscious rabbits, although higher doses of monensin were administered, 200 μg/kg intravenously and 10 mg/kg orally, its cardiovascular effects were less than observed in the dog and were slower in onset. This correlated with slower clearing of injected monensin from the blood (t 1 2= 8 min) and slower entry of ingested monensin from the gut into the blood. Rabbit plasma and tissue levels were higher 17 hr after oral ingestion of monensin than six hr after ingestion.