Aptamers against viral hepatitis: from rational design to practical application
Aptamers against viral hepatitis: from rational design to practical application
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DOI：
10.1007/s12250-008-2979-y
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发表时间：
2008-10
影响因子：
5.5
通讯作者：
Hui Feng;K. Hu
中科院分区：
文献类型：
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作者：
Hui Feng;K. Hu
Aptamers are short nucleic acids or peptides that strongly bind to a protein of interest and functionally inhibit a given target protein at the intracellular level. Besides high affinity and specificity, aptamers have several advantages over traditional antibodies. Hence, they have been broadly selected to develop antiviral agents for therapeutic applications against hepatitis B and C viruses (HBV, HCV). This review provides a summary ofin vitroselection and characterization of aptamers against viral hepatitis, which is of practical significance in drug discovery.
