Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors
Assessment of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors
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DOI：
10.1111/j.1440-1827.2010.02584.x
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发表时间：
2010-10-01
影响因子：
2.2
通讯作者：
McLeod, David G.
中科院分区：
文献类型：
--
作者：
Ali, Amina;Furusato, Bungo;McLeod, David G.
本研究的目的是评估根治性前列腺切除术 (RP) 后肿瘤体积小（小于 0.5 cc）的前列腺癌患者中循环肿瘤细胞 (CTC) 的发生率。从 64 名 RP 患者身上采集血样，以评估 RP 后 CTC 的发生率。标本采用整体切片处理。将临床病理学数据（例如患者年龄、种族、标本重量、肿瘤体积、分级、分期和手术切缘状态）和随访 PSA 数据与 CTC 状态进行比较。在 64 名 RP 患者中，有 9 名患有“小体积前列腺癌”。其中 7 名患者的 CTC 水平可检测到。在七名可检测到 CTC 的患者中，有两名患者还观察到 PSA 升高。在低容量前列腺癌患者中分离和检测循环上皮细胞是可能的。在低体积前列腺癌的情况下，CTC 可能与可检测到的 PSA 水平有关。然而，CTC 的检测并不能预测 PSA 失败。
The objective of this study was to assess the incidence of circulating tumor cells (CTCs) in prostate cancer patients with low-volume tumors (less than 0.5 cc) after radical prostatectomy (RP). Blood samples were collected from 64 RP patients to assess the incidence of CTCs following RP. The specimens were processed by whole-mount section. Clinicopathological data (e.g. patient age, race, specimen weight, tumor volume, grade, stage and surgical margin status) and follow-up PSA data were compared to CTC status. Of the 64 RP patients, nine had 'low-volume prostate cancer'. Seven of these patients had detectable levels of CTCs. In two of the seven patients with detectable CTCs, PSA elevation was also observed. Isolation and detection of circulating epithelial cells is possible in low-volume prostate cancer patients. In the setting of low-volume prostate cancer, CTCs may be associated with the presence of detectable PSA levels. However, the detection of CTCs did not predict PSA failure.